2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase

NADPH Oxidase

NOX

NADPH Oxidase

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NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

NADPH Oxidase Isoform Specific Products:

NADPH Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS09462
    Nox4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox4 Mouse Pre-designed siRNA Set A
  • HY-105946
    Hidrosmin
    		Inhibitor
    Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.
    Hidrosmin
  • HY-111447
    VAS 3947
    		Inhibitor 99.59%
    VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
    VAS 3947
  • HY-B0203B
    (Rac)-Nebivolol
    		Inhibitor
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
    (Rac)-Nebivolol
  • HY-N2641
    Dihydrotamarixetin
    		Inhibitor 99.91%
    Dihydrotamarixetin (4'-O-Methyldihydroquercetin; Blumeatin A) is a flavonoid with a saturated 2,3-bond and a non-catechol B ring. Dihydrotamarixetin acts as an inhibitor of NADPH Oxidase.
    Dihydrotamarixetin
  • HY-RS09461
    NOX4 Human Pre-designed siRNA Set A
    		Inhibitor

    NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NOX4 Human Pre-designed siRNA Set A
  • HY-12805R
    ML171 (Standard)
    		Inhibitor
    ML171 (Standard) is the analytical standard of ML171. This product is intended for research and analytical applications. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
    ML171 (Standard)
  • HY-160524
    NOX2-IN-3
    		Inhibitor 98.08%
    NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813).
    NOX2-IN-3
  • HY-172451
    MC4762
    		Inhibitor
    MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6.
    MC4762
  • HY-B0932R
    Levocarnitine propionate hydrochloride (Standard)
    		Inhibitor
    Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.
    Levocarnitine propionate hydrochloride (Standard)
  • HY-P1435A
    NoxA1ds TFA
    		Inhibitor
    NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM). NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors.
    NoxA1ds TFA
  • HY-157450
    YF-Mo1
    		Inhibitor
    YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC50 value of 1.1 μM.
    YF-Mo1
  • HY-N9097
    Niazirin
    		Inhibitor 99.9%
    Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.
    Niazirin
  • HY-136271
    MJ33
    		Inhibitor
    MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor with an IC50 of 0.3 μM. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer.
    MJ33
  • HY-RS09457
    NOX1 Human Pre-designed siRNA Set A
    		Inhibitor

    NOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NOX1 Human Pre-designed siRNA Set A
  • HY-174817
    NOX5-IN-1
    		Inhibitor
    NOX5-IN-1 (Compound 13) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.30  μM. NOX5-IN-1 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 0.86  μM). NOX5-IN-1 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation.
    NOX5-IN-1
  • HY-RS09459
    Nox1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Nox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox1 Rat Pre-designed siRNA Set A
  • HY-176757
    N-Benzyl-N-demethylpronqodine A
    		Inhibitor
    N-Benzyl-N-demethylpronqodine A (Compound 16) is an inhibitor of NAD(P)H:quinine acceptor oxidoreductase 1 (NQO1) with an IC50 of 83.3 nM.
    N-Benzyl-N-demethylpronqodine A
  • HY-B0203BS2
    (Rac)-Nebivolol-d2,15N
    		Inhibitor
    (Rac)-Nebivolol-d2,15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
    (Rac)-Nebivolol-d<sub>2</sub>,<sup>15</sup>N
  • HY-174818
    NOX5-IN-2
    		Inhibitor
    NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.70  μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 1.8  μM). NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation.
    NOX5-IN-2
Cat. No. Product Name / Synonyms Application Reactivity
NADPH Oxidase Isoform Comparison

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