2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis TGF-beta/Smad Epigenetics
  3. Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase
  4. Niazirin

Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis.

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Niazirin

Niazirin Chemical Structure

CAS No. : 122001-32-5

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Niazirin Related Antibodies

Top Publications Citing Use of Products

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GPX1 GPX4

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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NOX1 NOX2 NOX4 NOX5 DUOX1

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  • Customer Review

Description

Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits Nox4 protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis[1].

IC50 & Target[1]

PKCζ

 

NOX4

 

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
> 45 μM
Compound: 8
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS challenge
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS challenge
[PMID: 20685125]
In Vitro

Niazirin (2-64 μM; 24 h) dose-dependently inhibits high glucose-induced abnormal proliferation of porcine aortic VSMCs, with no effect on VSMCs under normal glucose conditions[1].
Niazirin (5-25 μM; 24 h) significantly reduces high glucose-induced ROS production in porcine aortic VSMCs[1].
Niazirin (5-25 μM; 48 h) reverses high glucose-induced oxidant-antioxidant imbalance in porcine aortic VSMCs by reducing MDA production and increasing T-AOC, GPx, and SOD levels[1].
Niazirin (5-25 μM) inhibits high glucose-induced activation of the PKCζ/Nox4 pathway in porcine aortic VSMCs by reducing PKCζ Thr410 phosphorylation and Nox4 protein expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Niazirin Related Antibodies

Cell Viability Assay[1]

Cell Line: porcine aortic vascular smooth muscle cells (VSMCs) under normal glucose (NG) or high glucose (HG) conditions
Concentration: 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time: 24 h
Result: Inhibited high glucose-induced VSMCs proliferation in a dose-dependent manner at all tested concentrations (p < 0.01).
Had no obvious effect on VSMCs growth under normal glucose conditions.
In Vivo

Niazirin (10-40 mg/kg; i.g.; daily; 14 days) improves antioxidant status, reduces oxidative stress, and inhibits vascular smooth muscle cell proliferation in Streptozotocin-induced diabetic mice, with the 40 mg/kg dose showing greater reductions in PKCζ phosphorylation, Nox4 expression, and Ki67 positive area[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 20-25 g, diabetes induced by 8 weeks of high fat and carbohydrate diet followed by streptozotocin injection)[1]
Dosage: 10 mg/kg; 40 mg/kg
Administration: i.g.; daily; 14 days
Result: Significantly increased serum total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels relative to diabetic controls (p < 0.05 for T-AOC, GPx; p < 0.01 for SOD) at 10 mg/kg.
Significantly decreased serum malondialdehyde (MDA) production relative to diabetic controls (p < 0.01) at 10 mg/kg.
Significantly reduced thoracic aorta PKCζ Thr410 phosphorylation and Nox4 protein expression relative to diabetic controls (p < 0.05 for both) at 10 mg/kg.
Reduced aortic Ki67 positive area in diabetic controls.
Significantly increased serum T-AOC, SOD, and GPx levels relative to diabetic controls at 40 mg/kg.
Significantly decreased serum MDA production relative to diabetic controls (p < 0.01) at 40 mg/kg.
Significantly reduced thoracic aorta PKCζ Thr410 phosphorylation and Nox4 protein expression relative to diabetic controls (p < 0.01 for both) at 40 mg/kg.
Molecular Weight

279.29

Formula

C14H17NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]([C@H]1O)O)[C@@H](O[C@H]1C)OC(C=C2)=CC=C2CC#N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Niazirin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niazirin122001-32-5Reactive Oxygen Species (ROS)SODGlutathione PeroxidasePKCNADPH OxidaseSuperoxide DismutaseProtein kinase CNOXvascular smooth muscle cellporcine aortic VSMCsPKCζNox4MDAROST-AOCGPxstreptozotocin-induced diabetic miceInhibitorinhibitorinhibit

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