Penicillin-binding protein (PBP) Inhibitor

Penicillin-binding protein (PBP) Inhibitors (20):

Cat. No.	Product Name	Effect	Purity

HY-183080

VNRX-14079	Inhibitor
VNRX-14079 is an antibacterial agent and PBP2 inhibitor, with an IC₅₀ value of 1.7 μM against wild-type Neisseria gonorrhoeae PBP2. VNRX-14079 forms a covalent bond with Ser310 of PBP2, interacts with multiple residues of PBP2 to stabilize the complex, and induces an inward conformational change of the β₃-β₄ loop in chimeric PBP2. VNRX-14079 exhibits antibacterial activity against Ceftriaxone (HY-B0712)-resistant Neisseria gonorrhoeae strains. VNRX-14079 can be used in the research of gonorrhea.

HY-B1286

Piperacillin sodium	Inhibitor	98.22%
Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam.

HY-126387

Moenomycin complex	Inhibitor	99.9%
Moenomycin complex is a class of antibacterial agents and PBP inhibitors, with K_d values ranging from 94 nM to 1690 nM against various bacterial PBPs. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs). Moenomycin complex is used in the research of bacterial infections.

HY-159688

Cefditoren	Inhibitor	98.14%
Cefditoren is a broad-spectrum oral active cephalosporin that acts as a penicillin-binding protein (PBP) inhibitor. Cefditoren binds to specific PBPs in Gram-positive and Gram-negative bacteria, thereby inhibiting cell wall synthesis. Cefditoren also reduces serum levels of the inflammatory biomarkers IL-6 and KL-6. Cefditoren can be used in research related to acute exacerbation of chronic bronchitis, pharyngitis-tonsillitis, uncomplicated skin and skin structure infections, respiratory tract infections, acute pyelonephritis, and enterococcal endocarditis.

HY-B0771A

Cefozopran hydrochloride	Inhibitor
Cefozopran (SCE-2787) hydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran hydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran hydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran hydrochloride can be used for the research of bacterial infections.

HY-B1286R

Piperacillin sodium (Standard)	Inhibitor
Piperacillin (sodium) (Standard) is the analytical standard of Piperacillin (sodium). This product is intended for research and analytical applications. Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam.

HY-B0771

Cefozopran	Inhibitor
Cefozopran (SCE-2787) is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran can be used for the research of bacterial infections.

HY-W013376

Norcyclizine	Inhibitor	99.88%
Norcyclizine is a piperazine compound that can be used for the synthesis of antimicrobial agents. 1-Benzhydrylpiperazine derivatives have been found to enhance the antibacterial activity of β-lactam antibiotics (Oxacillin, HY-B0925A) against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). This enhancement is likely achieved by inhibiting the allosteric site of PBP2a. Additionally, 1-Benzhydrylpiperazine can also serve as a pharmacological scaffold for the synthesis of anticancer agents.

HY-174459

Anti-MRSA agent 31	Inhibitor
Anti-MRSA agent 31 (Compound 6) is an *anti-methicillin-resistant Staphylococcus aureus* (MRSA) agent with a MIC of 97 μg/mL and a MBC of 781.25 μg/mL. Anti-MRSA agent 31 has a potent antibacterial activity and a strong Binding Protein 2a (PBP2a)** inhibitory activity.

HY-117736

Ro 09-1428	Inhibitor
Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections.

HY-181715

PBP1b-IN-1	Inhibitor
PBP1b-IN-1 is a penicillin-binding protein inhibitor, with an IC₅₀ of 0.042 μM against PBP1b of Streptococcus pneumoniae and an IC₅₀ of 7.6 μM against PBP3 of Escherichia coli. PBP1b-IN-1 exerts antibacterial activity by targeting penicillin-binding proteins to inhibit bacterial peptidoglycan cross-linking. PBP1b-IN-1 can be used in studies related to bacterial infections.

HY-106095

DQ 2556	Inhibitor
DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.

HY-178108

Anti-MRSA agent 35	Inhibitor
Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC₅₀s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .

HY-W740077

Cefozopran dihydrochloride	Inhibitor
Cefozopran (SCE-2787) dihydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran dihydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran dihydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran dihydrochloride can be used for the research of bacterial infections.

HY-165460

AM-112	Inhibitor
AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC₅₀ values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections.

HY-W747311

Ritipenem	Inhibitor
Ritipenem is a penicillin antibiotic, that targets penicillin-binding protein with good affinity (IC₅₀ in levels of ng/mL), and exhibits antibacterial properties. Ritipenem exhibits antiviral activity against Haemophilus influenzae.

HY-182396

YU253434	Inhibitor
YU253434 is a PBP3 inhibitor with an IC₅₀ of 2.5 μM against Pseudomonas aeruginosa PBP3. YU253434 contains a siderophore domain that facilitates its uptake into the periplasmic space of Gram-negative bacilli. YU253434 exhibits antibacterial activity against multidrug-resistant Gram-negative bacilli. YU253434 can be used in studies of multidrug-resistant Gram-negative bacterial infections.

HY-120366

WCK-5153	Inhibitor
WCK-5153 is a Penicillin-Binding Protein 2 (PBP2) inhibitor with an IC₅₀ of 0.14 μg/ml (for P. aeruginosa PBP2) and acts as a β-lactam enhancer against Pseudomonas aeruginosa. WCK-5153 can be used in studies of multidrug-resistant (MDR) pathogens.

HY-N14699

Diphenicillin	Inhibitor
Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci.

HY-B0771AR

Cefozopran hydrochloride (Standard)	Inhibitor
Cefozopran (SCE-2787) hydrochloride (Standard) is the analytical standard of Cefozopran hydrochloride. Cefozopran (SCE-2787) dihydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran dihydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran dihydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran dihydrochloride can be used for the research of bacterial infections.

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