DQ 2556
DQ 2556 is a semi-synthetic cephalosporin antibiotic. DQ-2556 exhibits significant activity against both Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria and Enterobacteriaceae infections. DQ 2556 exerts its bactericidal effect by interfering with cell division. DQ-2556 has a strong affinity for the penicillin-binding proteins (PBPs) of Escherichia coli: PBP1A/1B (IC₅₀ = 0.57-0.73 μg/mL) and PBP3 (IC₅₀ = 0.088 μg/mL). DQ-2556 demonstrates significant in vivo protective effects. DQ-2556 can be used in the development of injectable cephalosporins.
For research use only. We do not sell to patients.
- CAS No.: 102253-70-3
- Formula: C22H19N7O6S2
- Molecular Weight:541.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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β-lactam |
DQ-2556 is active against Gram-positive bacteria, sensitive to methicillin-resistant Staphylococcus (MIC90 = 1.56-3.13 μg/mL), highly active against Streptococcus (MIC90 ≤ 0.05 μg/mL), and has limited activity against Enterococcus (MIC90 = 50 μg/mL)[1][2].
DQ-2556 is active against Gram-negative bacteria, has an MIC₉₀ value of no more than 0.05 μg/mL against Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, etc. and sensitive to Haemophilus influenzae and Neisseria gonorrhoeae with MIC90 of 0.1 μg/mL[1][2].
DQ-2556 has the same or ≤ 4-fold MIC₉₀ value against Staphylococcus aureus, Escherichia coli, and Proteus mirabilis[1][2].
DQ-2556 (0.0008-12.5 μg, 4 h) induces the formation of filamentous and spherical structures in Escherichia coli, and also induced cell lysis at higher concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 102253-70-3
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Molecular Weight 541.56
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Formula C22H19N7O6S2
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SMILES
[O-]C(C1=C(C[N+]2=CC=C(C3=CN=CO3)C=C2)CS[C@@]([C@@H]4NC(/C(C5=CSC(N)=N5)=N\OC)=O)([H])N1C4=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DQ 2556 Related Classifications
HY-106095 Related Classifications
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