Ro 09-1428
Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections.
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- CAS No.: 134452-47-4
- 화학식: C31H31N11O10S3
- 분자량:813.84
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 134452-47-4
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분자량 813.84
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화학식 C31H31N11O10S3
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SMILES
O=C(C1=C(CSC2N1C(C2NC(/C(C3=CSC(N)=N3)=N/OC(C)(C)C(NNC(C4=CC=C(C(O)=C4)O)=O)=O)=O)=O)CSC5=CC(C)=NC6=NC(CO)=NN65)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Arisawa M, et al. In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. Antimicrob Agents Chemother. 1991 Apr;35(4):653-9. [Content Brief]
[2]. Jones R N, et al. In vitro evaluation of Ro 09-1227, a novel catechol-substituted cephalosporin[J]. Antimicrobial agents and chemotherapy, 1992, 36(1): 233-238. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 09-1428 Related Classifications
HY-117736 Related Classifications
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