134452-47-4
Chemical Structure
Ro 09-1428
- CAS No.: 134452-47-4
- Formula:C31H31N11O10S3
- Molecular Weight:813.84
IUPAC Name: (E)-7-(2-(2-aminothiazol-4-yl)-2-(((1-(2-(3,4-dihydroxybenzoyl)hydrazinyl)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-3-(((2-(hydroxymethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxy
InChIKey: CCOFMFVZORWSAE-KPRPFPDJSA-N
SMILES: O=C(C1=C(CSC2N1C(C2NC(/C(C3=CSC(N)=N3)=N/OC(C)(C)C(NNC(C4=CC=C(C(O)=C4)O)=O)=O)=O)=O)CSC5=CC(C)=NC6=NC(CO)=NN65)O
Biological Activity: Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections[1][2].
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Ro 09-1428 | Ro 09-1428 is a broad-spectrum parenteral cephalosporin. Ro 09-1428 has potent antibacterial activities against Pseudomonas aeruginosa and Acinetobacter caloaceticus, with MIC90s of 0.39 and 6.25 μg/mL, respectively, better than Ceftazidime (HY-B0593). Additionally, Ro 09-1428 shows high activity against Escherichia coli, Kkbsielia pneumoniae, Proteus mirabilis, P. aeruginosa, staphylococci, and more. Ro 09-1428 preferentially attacks PBP 3 for target in E. coli and P. aeruginosa, which is promising for research of septicemias and serious P. aeruginosa infections. | |||||||||||||||||||||
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References
- [1]. Arisawa M, et al. In vitro and in vivo evaluation of Ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. Antimicrob Agents Chemother. 1991 Apr;35(4):653-9. [Content Brief]
- [2]. Jones R N, et al. In vitro evaluation of Ro 09-1227, a novel catechol-substituted cephalosporin[J]. Antimicrobial agents and chemotherapy, 1992, 36(1): 233-238. [Content Brief]
