Antibacterial agent 351
Antibacterial agent 351 is a broad-spectrum antibacterial agent. Antibacterial agent 351 binds to the allosteric site of PBP2a, induces conformational changes, and reduces the level of PBP2a in MRSA. Antibacterial agent 351 acts as a DNA intercalator to interfere with bacterial DNA function. Antibacterial agent 351 disrupts bacterial redox homeostasis via excessive production of ROS and RNS, depletes intracellular GSH, induces lipid peroxidation, and triggers bacterial cell death. Antibacterial agent 351 enhances the activity of Metronidazole (HY-B0318) against anaerobic bacteria and extends the antibacterial spectrum of Metronidazole to aerobic bacteria. Antibacterial agent 351 can be used in the research of bacterial infections (including MRSA infections).
For research use only. We do not sell to patients.
- CAS No.: 2798832-23-0
- Formula: C29H28N8O7
- Molecular Weight:600.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 351 (0.25 × MIC - 8 × MIC) inhibits MRSA virulence factors in a dose-dependent manner, reducing auto-aggregation, decreasing hydrophobicity by ~18.6% at 0.5 × MIC, lowering EPS content to 62.5% of the control at 2 × MIC, and eradicating up to 35% of mature MRSA biofilm at 8 × MIC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antibacterial agent 351 (50 μg/mL) shows no acute toxicity to Galleria mellonella larvae when administered at a dose of 50 μg/mL, with a 100% survival rate within 5 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2798832-23-0
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Molecular Weight 600.58
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Formula C29H28N8O7
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SMILES
O=C1N(NC2=CC=C([N+]([O-])=O)C=C2)C(C3=C(C1=CC=C4)C4=C(N5CCN(CC(O)CN6C(C)=NC=C6[N+]([O-])=O)CC5)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 351 Related Classifications
HY-184284 Related Classifications
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- Antibacterial agent 351
- 2798832-23-0
- Antibacterial agent351
- Antibacterial agent-351
- Penicillin-binding protein (PBP)
- Bacterial
- DNA Alkylator/Crosslinker
- Reactive Oxygen Species (ROS)
- ROS
- aerobic bacteria
- DNA
- MRSA
- GSH
- RNS
- Galleria mellonella
- anaerobic bacteria
- penicillin binding protein 2a
- PBP2a
- Inhibitor
- inhibitor
- inhibit