Antibacterial agent 351 

Antibacterial agent 351 is a broad-spectrum antibacterial agent. Antibacterial agent 351 binds to the allosteric site of PBP2a, induces conformational changes, and reduces the level of PBP2a in MRSA. Antibacterial agent 351 acts as a DNA intercalator to interfere with bacterial DNA function. Antibacterial agent 351 disrupts bacterial redox homeostasis via excessive production of ROS and RNS, depletes intracellular GSH, induces lipid peroxidation, and triggers bacterial cell death. Antibacterial agent 351 enhances the activity of Metronidazole (HY-B0318) against anaerobic bacteria and extends the antibacterial spectrum of Metronidazole to aerobic bacteria. Antibacterial agent 351 can be used in the research of bacterial infections (including MRSA infections)^[1].

Antibacterial agent 351 (0.25 × MIC - 8 × MIC) inhibits MRSA virulence factors in a dose-dependent manner, reducing auto-aggregation, decreasing hydrophobicity by ~18.6% at 0.5 × MIC, lowering EPS content to 62.5% of the control at 2 × MIC, and eradicating up to 35% of mature MRSA biofilm at 8 × MIC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 351 (10 × MIC) exhibits potent in vivo anti-MRSA activity. When administered at 10 × MIC, it increases the 7-day survival rate of Galleria mellonella (greater wax moth) larvae infected with MRSA to 70%^[1].
Antibacterial agent 351 (50 μg/mL) shows no acute toxicity to Galleria mellonella larvae when administered at a dose of 50 μg/mL, with a 100% survival rate within 5 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

600.58

C₂₉H₂₈N₈O₇

2798832-23-0

O=C1N(NC2=CC=C([N+]([O-])=O)C=C2)C(C3=C(C1=CC=C4)C4=C(N5CCN(CC(O)CN6C(C)=NC=C6[N+]([O-])=O)CC5)C=C3)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu XM, et al. Naphthalimide-mediated multitargeting antibacterial actions to enhance efficacy and broaden antibacterial spectrum of nitroimidazolyl ethylalcohols. Bioorganic chemistry. 2026 Jun 09;180:110076.