2798832-23-0
Chemical Structure
Antibacterial agent 351
- CAS No.: 2798832-23-0
- Formula:C29H28N8O7
- Molecular Weight:600.58
InChIKey: UHTAUDMBWUHWHM-UHFFFAOYSA-N
SMILES: O=C1N(NC2=CC=C([N+]([O-])=O)C=C2)C(C3=C(C1=CC=C4)C4=C(N5CCN(CC(O)CN6C(C)=NC=C6[N+]([O-])=O)CC5)C=C3)=O
Biological Activity: Antibacterial agent 351 is a broad-spectrum antibacterial agent. Antibacterial agent 351 binds to the allosteric site of PBP2a, induces conformational changes, and reduces the level of PBP2a in MRSA. Antibacterial agent 351 acts as a DNA intercalator to interfere with bacterial DNA function. Antibacterial agent 351 disrupts bacterial redox homeostasis via excessive production of ROS and RNS, depletes intracellular GSH, induces lipid peroxidation, and triggers bacterial cell death. Antibacterial agent 351 enhances the activity of Metronidazole (HY-B0318) against anaerobic bacteria and extends the antibacterial spectrum of Metronidazole to aerobic bacteria. Antibacterial agent 351 can be used in the research of bacterial infections (including MRSA infections)[1].
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Antibacterial agent 351 | Antibacterial agent 351 is a broad-spectrum antibacterial agent. Antibacterial agent 351 binds to the allosteric site of PBP2a, induces conformational changes, and reduces the level of PBP2a in MRSA. Antibacterial agent 351 acts as a DNA intercalator to interfere with bacterial DNA function. Antibacterial agent 351 disrupts bacterial redox homeostasis via excessive production of ROS and RNS, depletes intracellular GSH, induces lipid peroxidation, and triggers bacterial cell death. Antibacterial agent 351 enhances the activity of Metronidazole (HY-B0318) against anaerobic bacteria and extends the antibacterial spectrum of Metronidazole to aerobic bacteria. Antibacterial agent 351 can be used in the research of bacterial infections (including MRSA infections). | |||||||||||||||||||||
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Keywords
