2. シグナル伝達
  3. Apoptosis
  4. Transferrin Receptor

Transferrin Receptor

TfR; CD71

Transferrin Receptor is a transmembrane glycoprotein. Transferrin Receptor consists of two isoforms, TfR1 and TfR2. Transferrin Receptor mediates the uptake of transferrin-iron complexes. Transferrin Receptor plays an important role in iron homeostasis as a gatekeeper regulating transferrin iron uptake. Transferrin Receptor is also considered as a proliferation marker and an attractive target for anticancer agents (e.g., a marker of poor prognosis in breast cancer). Transferrin Receptor is associated with a variety of cancers including acute leukemia and breast cancer[1][2][3][4][5][6].

Transferrin Receptor 関連製品 (40):

製品番号 製品名 製品効果 純度 構造式
  • HY-P3267
    Holo-Bovine Transferrin

    トランスフェリン

    		99.0%
    Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron.
    Holo-Bovine Transferrin
  • HY-P991047
    Anti-CD71/TfR1 Antibody Inhibitor ≥99.0%
    Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD71/TfR1 Antibody
  • HY-107928
    Iron dextran

    Iron dextran

    Iron dextran (Fe dextran) can be used in the study of iron-deficiency anemia in animals.
    Iron dextran
  • HY-P990051
    Delpacibart 98.06%
    Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research.
    Delpacibart
  • HY-P99797
    Pabinafusp alfa 98.89%
    Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.
    Pabinafusp alfa
  • HY-179528
    DIM-3,5-Cl2 Activator 99.18%
    DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with KD values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively. DIM-3,5-Cl2 acts as an inverse agonist to downregulate pro-oncogenic and proendometriotic gene products, and as an agonist to enhance NR4A1/2/Sp1/Sp4-mediated CD71 transactivation. DIM-3,5-Cl2 induces ferroptosis via ROS formation, lipoperoxidation, MDA production, and reduced GPX4, SLC7A11 expression. DIM-3,5-Cl2 induces apoptosis via PARP and caspase-3 cleavage, reduced BCL-2 expression, and inhibits cancer cell viability. DIM-3,5-Cl2 can be used for the research of triple negative breast cancer, endometriosis, and colorectal cancer.
    DIM-3,5-Cl2
  • HY-P992144
    Zareprumig Inhibitor
    Zareprumig is a human monoclonal antibody targeting CD20/MS4A1&CD71/TFRC.
    Zareprumig
  • HY-P992387
    INA01 Inhibitor
    INA01 is an unlabeled human monoclonal antibody targeting CD71/TFRC, which can be used in ELISA, FACS and functional assays. INA01 is promising for leukemia-related research.
    INA01
  • HY-P3267A
    Apo-Bovine Transferrin Activator
    Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe2+ to Fe3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research.
    Apo-Bovine Transferrin
  • HY-P2314
    HAIYPRH hydrochloride 99.97%
    HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier.
    HAIYPRH hydrochloride
  • HY-159569
    TfR-1-IN-1 Inhibitor
    TfR-1-IN-1 is a transferrin receptor-1 (TfR-1) inhibitor with tumor cell-specific activity. TfR-1-IN-1 reduces TfR-1 expression, impairs mitochondrial function, induces cell apoptosis, necroptosis and ferroptosis, and increases intracellular iron (II) levels. TfR-1-IN-1 decreases the metabolic activity of cancer cells. TfR-1-IN-1 can be used for the research of ovarian cancer, breast cancer and acute myeloid leukemia.
    TfR-1-IN-1
  • HY-P2297
    TfR-T12 99.72%
    TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
    TfR-T12
  • HY-130078
    Ferrous bisglycinate 98.0%
    Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia.
    Ferrous bisglycinate
  • HY-P990129
    Anti-Mouse CD71/TfR1 Antibody (8D3) Inhibitor
    Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection.
    Anti-Mouse CD71/TfR1 Antibody (8D3)
  • HY-172723
    DSPE-PEG2000-T7 Ligand
    DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease.
    DSPE-PEG2000-T7
  • HY-P11099
    Cys-LT7 Ligand 99.90%
    Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma.
    Cys-LT7
  • HY-P990856
    Anti-CD71 Antibody (OKT-9) Inhibitor 99.60%
    Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma.
    Anti-CD71 Antibody (OKT-9)
  • HY-B1651
    Iron(II) fumarate

    Ferrous fumarate

    Iron (II) fumarate is an orally effective active dietary supplement. Iron (II) fumarate can alleviate metabolic damage and damage to silkworms caused by cypermethrin (HY-123178). Iron (II) fumarate can be used for research on iron deficiency anemia.
    Iron(II) fumarate
  • HY-D2426
    Cy3-Transferrin
    Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron.
    Cy3-Transferrin
  • HY-P990130
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain.
    Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)