Pabinafusp alfa
Based on 1 Customer Validation
Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.
For research use only. We do not sell to patients.
- Purity : 98.89%
- CAS No.: 2140211-48-7
- Molecular Weight:265.16 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target
Transferrin receptor[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse model of MPS II[1]
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Dosage:0.1 mg/kg, 0.5 mg/kg, and 2 mg/kg
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Administration:Intravenous injection; once weekly for 36 weeks
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Result:Dose-dependently decreases the level of heparan sulfate (HS) in the brain and cerebrospinal fluid (CSF), as well as decreasing the substrate concentrations.
Recovered spontaneous alterations in a dose-dependent manner, indicating an impaired working memory prevented.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2140211-48-7
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Appearance Liquid
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Molecular Weight 265.16 kDa
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Color Colorless to light yellow
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SMILES
[Pabinafusp alfa]
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Synonyms
JR-141
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pabinafusp alfa Related Classifications
HY-P99797 Related Classifications
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