2. Apoptosis
  3. Transferrin Receptor
  4. Cys-LT7

Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma.

For research use only. We do not sell to patients.

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Cys-LT7

Cys-LT7 Chemical Structure

CAS No. : 1254540-73-2

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Based on 1 publication(s) in Google Scholar

Cys-LT7 Related Antibodies

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Description

Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma[1].

In Vitro

Cys-LT7 conjugated with Doxorubicin exhibits poor serum stability in mouse serum, with a half-life of 0.37 h and nearly complete degradation by 1 h[1].
Cys-LT7 conjugated with Doxorubicin undergoes rapid reduction-triggered degradation in 5 mM GSH (complete degradation by 1 h, T1/2 = 0.26 h) and slower degradation in 5 µM GSH (71.4% intact after 24 h)[1].
Cys-LT7 conjugated with Doxorubicin is selectively taken up into the cytoplasm of TfR-overexpressed A549, HepG2, and U87 tumor cells (with time-dependent uptake) but shows minimal uptake into TfR-low-expressed LO2 normal cells[1].
Cys-LT7 conjugated with Doxorubicin exhibits weak in vitro antiproliferative activity against TfR-overexpressed U87, HepG2, and A549 tumor cells, with higher cell viability maintained even at an equivalent Doxorubicin concentration of 40 µM after 48 h of incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cys-LT7 Related Antibodies
Molecular Weight

996.15

Formula

C44H65N15O10S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-His-Ala-Ile-Tyr-Pro-Arg-His
Sequence Shortening

CHAIYPRH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (100.39 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0039 mL 5.0193 mL 10.0386 mL
5 mM 0.2008 mL 1.0039 mL 2.0077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0039 mL 5.0193 mL 10.0386 mL 25.0966 mL
5 mM 0.2008 mL 1.0039 mL 2.0077 mL 5.0193 mL
10 mM 0.1004 mL 0.5019 mL 1.0039 mL 2.5097 mL
15 mM 0.0669 mL 0.3346 mL 0.6692 mL 1.6731 mL
20 mM 0.0502 mL 0.2510 mL 0.5019 mL 1.2548 mL
25 mM 0.0402 mL 0.2008 mL 0.4015 mL 1.0039 mL
30 mM 0.0335 mL 0.1673 mL 0.3346 mL 0.8366 mL
40 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6274 mL
50 mM 0.0201 mL 0.1004 mL 0.2008 mL 0.5019 mL
60 mM 0.0167 mL 0.0837 mL 0.1673 mL 0.4183 mL
80 mM 0.0125 mL 0.0627 mL 0.1255 mL 0.3137 mL
100 mM 0.0100 mL 0.0502 mL 0.1004 mL 0.2510 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cys-LT7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cys-LT71254540-73-2Transferrin ReceptorTfRCD71TfR-low-expressed normal cellsA549LO2lung carcinomaTransferrin receptorhepatocellular carcinomaU87HepG2glioblastomaTfR-overexpressed tumor cellsInhibitorinhibitorinhibit

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