Ferrous bisglycinate

Name: Ferrous bisglycinate
Brand: MedChemExpress
SKU: HY-130078
Rating: 4.5 (1 reviews)

Cat. No.: HY-130078 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia.

For research use only. We do not sell to patients.

Ferrous bisglycinate Chemical Structure

CAS No. : 20150-34-9

Size	Price	Stock	Quantity
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia^[1]^[2].

In Vitro

Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability^[2].
Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Caco-2 cells
Concentration:	0, 25, 50, 100, 200 μM
Incubation Time:	2 hours
Result:	Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells.

Western Blot Analysis^[2]

Cell Line:	Caco-2 cells
Concentration:	25 μM
Incubation Time:	2 hours
Result:	Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells.

In Vivo

Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)^[3]
Dosage:	500 mg/kg iron
Administration:	P.o. (add to the diet) for 10 days
Result:	Had the best survival rates (100%). Caused the least body lost (9% body loss).

Clinical Trial

Molecular Weight

201.95

Formula

C₄H₆FeN₂O₄

CAS No.

20150-34-9

Appearance

Solid

Color

Light brown to green

SMILES

O=C1[O-][Fe+2]2([O-]C(CN2)=O)NC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

0.1 M HCL : 2 mg/mL (9.90 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9517 mL	24.7586 mL	49.5172 mL
5 mM	0.9903 mL	4.9517 mL	9.9034 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (9.90 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (251 KB) HNMR (257 KB)

Handling Instructions (2659 KB)

References

[1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8. [Content Brief]

[2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485. [Content Brief]

[3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

0.1 M HCL	1 mM	4.9517 mL	24.7586 mL	49.5172 mL	123.7930 mL
0.1 M HCL	5 mM	0.9903 mL	4.9517 mL	9.9034 mL	24.7586 mL