Ferrous bisglycinate
Based on 1 Customer Validation
Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 20150-34-9
- Formula: C4H8FeN2O4
- Molecular Weight:203.96
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability[2].
Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 cells
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Concentration:0, 25, 50, 100, 200 μM
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Incubation Time:2 hours
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Result:Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells.
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Cell Line:Caco-2 cells
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Concentration:25 μM
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Incubation Time:2 hours
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Result:Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)[3]
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Dosage:500 mg/kg iron
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Administration:P.o. (add to the diet) for 10 days
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Result:Had the best survival rates (100%).
Caused the least body lost (9% body loss).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 20150-34-9
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Appearance Solid
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Molecular Weight 203.96
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Formula C4H8FeN2O4
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Color Brown to breen
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SMILES
O=C1[O-][Fe+2]2([O-]C(CN2)=O)NC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
0.1 M HCl : 2 mg/mL (9.81 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (9.81 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8. [Content Brief]
[2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485. [Content Brief]
[3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M HCl | 1 mM | 4.9029 mL | 24.5146 mL | 49.0292 mL | 122.5730 mL |
| 5 mM | 0.9806 mL | 4.9029 mL | 9.8058 mL | 24.5146 mL |
Ferrous bisglycinate Related Classifications
HY-130078 Related Classifications
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