2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Tavilermide

Tavilermide  (Synonyms: MIM-D3)

製品番号: HY-17622 純度: 99.57%
COA 取扱説明書 Technical Support

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

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Tavilermide

Tavilermide 構造式

CAS 番号 : 263251-78-1

容量 価格（税別） 在庫状況 数量
5 mg $400 在庫あり
10 mg $640 在庫あり
25 mg $1280 在庫あり
50 mg $1920 在庫あり
100 mg $2500 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Tavilermide 関連抗体

Top Publications Citing Use of Products

Trk Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TrkA TrkB TrkC Trk

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.

IC50 & Target

TrkA

 

体外実験

Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tavilermide 関連抗体
臨床実験
分子量

580.54

分子式

C24H32N6O11
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC[C@H](N1)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(O)=O)=O)CCOC2=CC=C([N+]([O-])=O)C=C2C1=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

NH4OH : 50 mg/mL (86.13 mM; ultrasonic and adjust pH to 10 with NH4OH)

H2O : 2 mg/mL (3.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7225 mL 8.6127 mL 17.2253 mL
5 mM 0.3445 mL 1.7225 mL 3.4451 mL
10 mM 0.1723 mL 0.8613 mL 1.7225 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 4.17 mg/mL (7.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • Protocol 2

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 25 mg/mL (43.06 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.57%

COA (253 KB) LCMS (98 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / NH4OH 1 mM 1.7225 mL 8.6127 mL 17.2253 mL 43.0634 mL
NH4OH 5 mM 0.3445 mL 1.7225 mL 3.4451 mL 8.6127 mL
10 mM 0.1723 mL 0.8613 mL 1.7225 mL 4.3063 mL
15 mM 0.1148 mL 0.5742 mL 1.1484 mL 2.8709 mL
20 mM 0.0861 mL 0.4306 mL 0.8613 mL 2.1532 mL
25 mM 0.0689 mL 0.3445 mL 0.6890 mL 1.7225 mL
30 mM 0.0574 mL 0.2871 mL 0.5742 mL 1.4354 mL
40 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0766 mL
50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.8613 mL
60 mM 0.0287 mL 0.1435 mL 0.2871 mL 0.7177 mL
80 mM 0.0215 mL 0.1077 mL 0.2153 mL 0.5383 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tavilermide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tavilermide263251-78-1MIM-D3Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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製品名:
Tavilermide
製品番号:
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