1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
    nAChR

Vinblastine 

Cat. No.: HY-17418 Purity: 98.38%
Handling Instructions

Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

For research use only. We do not sell to patients.
Vinblastine Chemical Structure

Vinblastine Chemical Structure

CAS No. : 865-21-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $120 In-stock
100 mg $200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.

IC50 & Target

IC50: 8.9 μM(nAChR)[1]

In Vitro

Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4].

In Vivo

Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5].

References
M.Wt

810.97

Formula

C₄₆H₅₈N₄O₉

CAS No.

865-21-4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 42 mg/mL

Purity: 98.38%

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Product Name:
Vinblastine
Cat. No.:
HY-17418
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