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Vinblastine

HY-17418

Vinblastine

Vinblastine Chemical Structure

Vinblastine can inhibit the formation of microtubule, it also inhibit nAChR(IC50=8.9 uM).

Size Price Stock Quantity
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $120 In-stock
100 mg $200 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €54 In-stock
10 mg €49 In-stock
50 mg €118 In-stock
100 mg €196 In-stock
200 mg Get quote
500 mg Get quote

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Product name: Vinblastine
Cat. No.: HY-17418

Vinblastine Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Vinblastine

Vinblastine can inhibit the formation of microtubule, it also inhibit nAChR(IC50=8.9 uM).
IC50 Value: VIN showed EC50 values of 15 ug/ml, against P815 mastocytoma cells in-vitro[1]. Also supresses nAChR activity with IC50 of 8.9 μM.
Target: Microtubule/nAChR
in vitro: At vinblastine concentrations of 0.5 uM and 2 uM, considerable inhibition of metabolic degradation of vinblastine was observed by competitive inhibitors of CYP3A4 (up to 60% inhibition), 2D6 (30%) and 2E1 (24%), while only a minor effect was observed for 2C9 (14%) and inhibitors of 1A2, 2C8 had no inhibitory effect on vinblastine metabolism. Vinblastine (0.5 and 2 uM) inhibited the metabolic capacity of CYP2C9 (up to 56%), 2C8 (36%), 2D6 (22%) and 3A4-mediated nifedipine oxidation (99%), while 3A4-mediated testosterone 6-beta-hydroxylation (max. 16%) as well as 1A2 and 2E1 remained unaffected[3].
in vivo: In combined intraperitoneal injection with vinblastine (200 micrograms kg-1) into P388/ADR-bearing mice, NA-382 in a suspension form (10 mg kg-1) prolonged the life-span of the mice near to that of P388/S-bearing mice treated with vinblastine alone, but verapamil even at the maximum tolerated dosage (30 mg kg-1) barely affected the in-vivo antitumour effect of vinblastine[2].
Clinical trial: Combination Chemotherapy With or Without Interleukin-2 and Interferon Alfa in Treating Patients With Metastatic Melanoma . Phase 3 Clinical
 

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 810.97 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₆H₅₈N₄O₉
CAS No 865-21-4
Solvent & Solubility

DMSO: ≥ 42 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.2331 mL 6.1655 mL 12.3309 mL
5 mM 0.2466 mL 1.2331 mL 2.4662 mL
10 mM 0.1233 mL 0.6165 mL 1.2331 mL

References on Vinblastine

Other Forms

Inhibitor Kit

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