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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Cevipabulin

HY-14949

(TTI-237)

Cevipabulin

Cevipabulin Chemical Structure

Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $154 In-stock
5 mg $140 In-stock
10 mg $240 In-stock
50 mg $740 In-stock
100 mg $950 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €151 In-stock
5 mg €137 In-stock
10 mg €235 In-stock
50 mg €725 In-stock
100 mg €931 In-stock
200 mg Get quote
500 mg Get quote

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Product name: Cevipabulin
Cat. No.: HY-14949

Cevipabulin Data Sheet

  • View current batch:

    Purity: 97.04%

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Cevipabulin

Cevipabulin(TTI-237) is a novel, potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.
IC50 value:
Target: Antimicrotubule agent
in vitro: TTI-237 inhibited the binding of [(3)H]vinblastine to tubulin, but it caused a marked increase in turbidity development that more closely resembled the effect observed with docetaxel than that observed with vincristine. When applied to cultured human tumor cells at concentrations near its IC(50) value for cytotoxicity (34 nmol/L), TTI-237 induced multiple spindle poles and multinuclear cells, as did paclitaxel, but not vincristine or colchicine. Flow cytometry experiments revealed that, at low concentrations (20-40 nmol/L), TTI-237 produced sub-G(1) nuclei and, at concentrations above 50 nmol/L, it caused a strong G(2)-M block. The compound was a weak substrate of multidrug resistance 1 (multidrug resistance transporter or P-glycoprotein). In a cell line expressing a high level of P-glycoprotein, the IC(50) of TTI-237 increased 25-fold whereas those of paclitaxel and vincristine increased 806-fold and 925-fold, respectively. TTI-237 was not recognized by the MRP or MXR transporters [1].  TTI-237 inhibited the exchange of [(3)H]GTP at the exchangeable nucleotide site of the tubulin heterodimer, and was similar to vincristine in its effects on the phosphorylation of eight intracellular proteins in HeLa cells [3].
in vivo: TTI-237 was active in vivo in several nude mouse xenograft models of human cancer, including LoVo human colon carcinoma and U87-MG human glioblastoma, when dosed i.v. or p.o [1].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 464.82 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₈H₁₈ClF₅N₆O
CAS No 849550-05-6
Solvent & Solubility

DMSO: 10 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.1514 mL 10.7569 mL 21.5137 mL
5 mM 0.4303 mL 2.1514 mL 4.3027 mL
10 mM 0.2151 mL 1.0757 mL 2.1514 mL

References on Cevipabulin

Inhibitor Kit

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