1. Peptides

Pristinamycin IA (Synonyms: Mikamycin B; Mikamycin IA)

Cat. No.: HY-A0279A Purity: 95.60%
Handling Instructions

Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pristinamycin IA Chemical Structure

Pristinamycin IA Chemical Structure

CAS No. : 3131-03-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 481 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 504 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein. In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (32.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1535 mL 5.7673 mL 11.5346 mL
5 mM 0.2307 mL 1.1535 mL 2.3069 mL
10 mM 0.1153 mL 0.5767 mL 1.1535 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

866.96

Formula

C₄₅H₅₄N₈O₁₀

CAS No.

3131-03-1

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Pristinamycin IA
Cat. No.:
HY-A0279A
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Pristinamycin IA

Cat. No.: HY-A0279A