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  3. Pristinamycin IA

Pristinamycin IA  (Synonyms: Mikamycin B; Mikamycin IA)

Cat. No.: HY-A0279A Purity: 98.81%
COA Handling Instructions

Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus.

For research use only. We do not sell to patients.

Pristinamycin IA Chemical Structure

Pristinamycin IA Chemical Structure

CAS No. : 3131-03-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 481 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 481 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 312 In-stock
Estimated Time of Arrival: December 31
10 mg USD 504 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pristinamycin IA:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pristinamycin IA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

In Vitro

Pristinamycin IA (100 μM, 0-4 h) inhibits the efflux of [3H]vinblastine from Caco-2 cells[1].
Pristinamycin IA (100 μM) reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers[1].
Pristinamycin IA (4.614 μM) activates ribosome-dependent ribo-regulator (LRR)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

866.96

Formula

C45H54N8O10

CAS No.
SMILES

O=C(N[[email protected]@H]1C(N[[email protected]](CC)C(N2[[email protected]](CCC2)([H])C(N(C)[[email protected]@H](CC3=CC=C(N(C)C)C=C3)C(N4[[email protected]](CC(CC4)=O)([H])C(N[[email protected]@H](C5=CC=CC=C5)C(O[[email protected]@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O

Structure Classification
Source

Streptomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (38.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1535 mL 5.7673 mL 11.5346 mL
5 mM 0.2307 mL 1.1535 mL 2.3069 mL
10 mM 0.1153 mL 0.5767 mL 1.1535 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (3.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (3.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (3.46 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.81%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pristinamycin IA
Cat. No.:
HY-A0279A
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