1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Pristinamycin

Pristinamycin  (Synonyms: Pristinamycine)

Cat. No.: HY-A0279
Handling Instructions

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF).

For research use only. We do not sell to patients.

Pristinamycin Chemical Structure

Pristinamycin Chemical Structure

CAS No. : 270076-60-3

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 Get quote
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF)[1].

In Vitro

In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1392.55

Formula

C73H89N11O17

CAS No.
SMILES

O=C(N[[email protected]@H]1C(N[[email protected]](CC)C(N2[[email protected]](CCC2)([H])C(N(C)[[email protected]@H](CC3=CC=C(N(C)C)C=C3)C(N4[[email protected]](CC(CC4)=O)([H])C(N[[email protected]@H](C5=CC=CC=C5)C(O[[email protected]@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O.O=C7N8C(C(O[[email protected]@H]([[email protected]@H](/C=C/C(NC/C=C/C(C)=C/[[email protected]](CC(CC9=NC7=CO9)=O)O)=O)C)C(C)C)=O)=CCC8

Structure Classification
Source

streptogramin

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pristinamycin
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HY-A0279
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