1. Anti-infection
  2. Bacterial
  3. Pristinamycin

Pristinamycin (Synonyms: Pristinamycine)

Cat. No.: HY-A0279
Handling Instructions

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF).

For research use only. We do not sell to patients.

Pristinamycin Chemical Structure

Pristinamycin Chemical Structure

CAS No. : 270076-60-3

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Description

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF)[1].

In Vitro

In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2].

In Vivo

To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3].

Molecular Weight

1392.55

Formula

C₇₃H₈₉N₁₁O₁₇

CAS No.

270076-60-3

SMILES

O=C(N[[email protected]@H]1C(N[[email protected]](CC)C(N2[[email protected]](CCC2)([H])C(N(C)[[email protected]@H](CC3=CC=C(N(C)C)C=C3)C(N4[[email protected]](CC(CC4)=O)([H])C(N[[email protected]@H](C5=CC=CC=C5)C(O[[email protected]@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O.O=C7N8C(C(O[[email protected]@H]([[email protected]@H](/C=C/C(NC/C=C/C(C)=C/[[email protected]](CC(CC9=NC7=CO9)=O)O)=O)C)C(C)C)=O)=CCC8

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PristinamycinPristinamycineBacterialoralpathogensresistantGram-positivebacteriaInhibitorinhibitorinhibit

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