1. Anti-infection
  2. Bacterial
  3. Pristinamycin

Pristinamycin (Synonyms: Pristinamycine)

Cat. No.: HY-A0279
Handling Instructions

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF).

For research use only. We do not sell to patients.

Pristinamycin Chemical Structure

Pristinamycin Chemical Structure

CAS No. : 270076-60-3

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Description

Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF)[1].

In Vitro

In-vitro studies show pristinamycin to inhibit Staphylococci and Streptococci, including Erythromycin highly-resistant organisms, at a concentration of less than or equal to 0.78 mg/l[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

To study Pristinamycin activity in vivo, mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg Pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1392.55

Formula

C₇₃H₈₉N₁₁O₁₇

CAS No.
SMILES

O=C(N[[email protected]@H]1C(N[[email protected]](CC)C(N2[[email protected]](CCC2)([H])C(N(C)[[email protected]@H](CC3=CC=C(N(C)C)C=C3)C(N4[[email protected]](CC(CC4)=O)([H])C(N[[email protected]@H](C5=CC=CC=C5)C(O[[email protected]@H]1C)=O)=O)=O)=O)=O)=O)C6=NC=CC=C6O.O=C7N8C(C(O[[email protected]@H]([[email protected]@H](/C=C/C(NC/C=C/C(C)=C/[[email protected]](CC(CC9=NC7=CO9)=O)O)=O)C)C(C)C)=O)=CCC8

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PristinamycinPristinamycineBacterialoralpathogensresistantGram-positivebacteriaInhibitorinhibitorinhibit

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