2. Metabolic Enzyme/Protease Apoptosis
  3. Carnitine Palmitoyltransferase (CPT) Apoptosis
  4. Etomoxir sodium salt

Etomoxir (sodium salt)  (Synonyms: Etomoxir; (R)-(+)-Etomoxir (sodium salt))

製品番号: HY-50202A 純度: 99.62%
COA 取扱説明書 Technical Support

Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.

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CAS 番号 : 828934-41-4

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 在庫あり
Solution
10 mM * 1 mL in DMSO USD 77 在庫あり
Solid
5 mg $70 在庫あり
10 mg $110 在庫あり
25 mg $190 在庫あり
50 mg $340 在庫あり
100 mg $550 在庫あり
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カスタマーレビュー

Based on 128 publication(s) in Google Scholar

Other Forms of Etomoxir sodium salt:

Etomoxir (sodium salt) 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Proliferation/Viability Assay
Bio/Physico-chemical Assay
WB

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Apr 22:S1535-6108(25)00138-2.  [Abstract]

    Relative confluence of A375 cells treated with young secretome (YA, blue) and YA secretome containing Etomoxir (10 µM; 40 h) (YA Etomoxir, white circles).

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Nat Genet. 2025 Mar;57(3):680-693.

    A375 cells treated with IFN-γ and Etomoxir (100,200 μM; 24 h) were analyzed for PD-L1 expression.

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep 30.  [Abstract]

    Luminescence detection of intracellular ATP (a.u., arbitrary units) in cultured hippocampal E16 Ddhd2−/− neurons ±1 µM M-CoA for 48 h and ± etomoxir (1 μM; 48 h) analysed at DIV 21–22 normalized to the average of Ddhd2−/− in each experiment.

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 May 7;36(5):969-983.e10.  [Abstract]

    Etomoxir (10 mM; 20 min). Energetic profiling, OCR trace with SRC quantifications of OT-1 T cells cultured ± ACCi.

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Dec 5;35(12):2136-2152.e9.  [Abstract]

    Etomoxir（50 μM; 6 days）.Seahorse respirometry and measurement of the oxygen consumption rate (OCR) in WT (D and F) or Lepr-cKO (E) nerve explants.

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Feb 15;14(2):125.  [Abstract]

    Etomoxir reduces the proliferation of 143b cells.

    Etomoxir sodium salt purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Oct 11;7(41):67071-67086.  [Abstract]

    MDA-MB-453 cells are treated as indicated for 2 days and subjected to immunoblotting. Combination treatments using non-saturating doses of Etomoxir and MTI-31 or Rapamycin results in an enhanced growth suppression in MDA-MB-453 cells, which is not readily observed in MDA-MB-231 cells, correlating a nearly complete suppression of cyclin D1 and c-Myc level in MDA-MB-453 cells under the combination treatments.

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    製品説明

    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig[1].

    IC50 & Target

    CPT-1A

     

    体外実験

    Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells[2].
    Etomoxir does not affect the activities of the cardiolipin biosynthetic and remodeling enzymes but causes a reduction in [1-14C]palmitic acid or [1-14C]oleic acid incorporation into cardiolipin[2].
    Etomoxir increases [1,3-3H]glycerol incorporation into cardiolipin. The mechanism is a 33% increase in glycerol kinase activity, which produces an increased glycerol flux through the de novo pathway of cardiolipin biosynthesis[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Etomoxir (sodium salt) 関連抗体

    Cell Viability Assay[2]

    Cell Line: Rat heart H9c2 myoblastic cells
    Concentration: 1-80 μM
    Incubation Time: 2 hours
    Result: Reduced the incorporation of [1-14C]fatty acids into CL and PtdGro in H9c2 cardiac myoblast cells but did not affect total incorporation of radioactivity into these cells.
    体内実験

    Etomoxir significantly inhibits the decrease of bone mineral density (BMD) and bone breaking strength in db/db and high fat (HF)-fed mice and suppresses the reduction of BMSCs-differentiated osteoblasts[3].
    Etomoxir inhibits the increase of mitochondrial ROS generation in db/db and HF-fed mice and osteoblasts[3].
    Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates[4]

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 80 male C57BLKS/J lar-Leprdb/db mice[3]
    Dosage: 1 mg/kg
    Administration: Intraperitoneally injected; twice every week
    Result: Serum alkaline phosphatase was increased in db/db mice, which event was significantly suppressed by Etomoxir. Serum level of osteocalcin, a marker of bone formation, was reduced in db/db mice and Etomoxir markedly inhibited the reduction of osteocalcin. Serum tartrate-resistant acid phosphatase was elevated in db/db mice which phenomenon was significantly suppressed by Etomoxir.
    Animal Model: Rats[4]
    Dosage: 20 mg/kg
    Administration: Injected daily; for 8 days
    Result: Etomoxir-treated rats displayed a 44% reduced cardiac CPT-I activity.
    分子量

    320.74

    分子式

    C15H18ClNaO4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    ClC1=CC=C(OCCCCCC[C@@]2(CO2)C(O[Na])=O)C=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 50 mg/mL (155.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 5 mg/mL (15.59 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1178 mL 15.5890 mL 31.1779 mL
    5 mM 0.6236 mL 3.1178 mL 6.2356 mL
    10 mM 0.3118 mL 1.5589 mL 3.1178 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (7.79 mM); Clear solution; Need ultrasonic

      This protocol yields a clear solution of 2.5 mg/mL.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.79 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 3.33 mg/mL (10.38 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.62%

    COA (243 KB) HNMR (251 KB) RP-HPLC (245 KB) LCMS (88 KB) OR (171 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light, stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.1178 mL 15.5890 mL 31.1779 mL 77.9448 mL
    5 mM 0.6236 mL 3.1178 mL 6.2356 mL 15.5890 mL
    10 mM 0.3118 mL 1.5589 mL 3.1178 mL 7.7945 mL
    15 mM 0.2079 mL 1.0393 mL 2.0785 mL 5.1963 mL
    DMSO 20 mM 0.1559 mL 0.7794 mL 1.5589 mL 3.8972 mL
    25 mM 0.1247 mL 0.6236 mL 1.2471 mL 3.1178 mL
    30 mM 0.1039 mL 0.5196 mL 1.0393 mL 2.5982 mL
    40 mM 0.0779 mL 0.3897 mL 0.7794 mL 1.9486 mL
    50 mM 0.0624 mL 0.3118 mL 0.6236 mL 1.5589 mL
    60 mM 0.0520 mL 0.2598 mL 0.5196 mL 1.2991 mL
    80 mM 0.0390 mL 0.1949 mL 0.3897 mL 0.9743 mL
    100 mM 0.0312 mL 0.1559 mL 0.3118 mL 0.7794 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Etomoxir sodium salt Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
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    Keywords:

    Etomoxir828934-41-4(R)-(+)-EtomoxirCarnitine Palmitoyltransferase (CPT)ApoptosisCarnitine O-palmitoyltransferaseirreversiblecarnitinepalmitoyltransferase1aCPT-1afattyacidoxidationFAOpalmitateβ-oxidationInhibitorinhibitorinhibit

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    製品名:
    Etomoxir sodium salt
    製品番号:
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