AKT Kinase Inhibitor hydrochloride

Name: AKT Kinase Inhibitor hydrochloride
Brand: MedChemExpress
SKU: HY-10249D
Rating: 5.0 (16 reviews)

製品番号: HY-10249D 純度: 99.39%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 3026697-00-4

容量	価格（税別）	在庫状況	数量
5 mg	$420	在庫あり	Estimated Time of Arrival: December 31
10 mg	$720	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1120	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1500	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2000	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 16 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor hydrochloride:

AKT Kinase Inhibitor 在庫あり
AKT Kinase Inhibitor hydrochloride (Standard) お問い合わせ

顧客検証

Cell Migration/Invasion Assay

RT-PCR

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 May 18:107218. [Abstract]; Stimulation of B16-F10 cells with TAM-conditioned medium, pre-treated with AKT Kinase Inhibitor (5 μM) for 24 h. Western blot assessing AKT phosphorylation, AKT baseline expression, and STC1 expression.

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 May 18:107218. [Abstract]; Stimulation of B16-F10 cells with TAM-conditioned medium, pre-treated with AKT kinase inhibitor (5 μM) for 24 h. CCL2 mRNA expression was detected by qPCR.

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Apr 29;20(7):2748-2762. [Abstract]; Western blotting analysis of Akt1, p-Akt1 (Ser473), lamin A/C, and p-lamin A/C (Ser22) in SW480 LNCs treated with or without AKT Kinase Inhibitor (Akti; 0.5 μM).

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9. [Abstract]; Immunofluorescence of LIN28A at the end of stage I under SI_BMP4/B27+AKTi (AKT Kinase Inhibitor: 1 μM) +VTP+J condition.

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Small. 2023 Apr;19(16):e2207194. [Abstract]; AKT Kinase Inhibitor (10 μM). Comparison of migration restriction ability of SK-Hep-1, SNU-449, PANC-1, SW1990 and primary cancer-associated fibroblasts.

: AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2020 Jun 24;2020:3621261. [Abstract]; After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Akt Akt1 Akt2 Akt3

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity^[1]. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外実験

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

393.83

分子式

C₁₆H₂₀ClN₇O₃

CAS 番号

3026697-00-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 20 mg/mL (50.78 mM; Need ultrasonic)

DMSO : 5.88 mg/mL (14.93 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5392 mL	12.6958 mL	25.3917 mL
5 mM	0.5078 mL	2.5392 mL	5.0783 mL
10 mM	0.2539 mL	1.2696 mL	2.5392 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.39%

Select Batch:

データシート (274 KB) SDS (252 KB)

COA (251 KB) HNMR (484 KB) RP-HPLC (205 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Saverio Alberti, et al. Use of trop-2 as predictive marker of response to anti-tumor therapy based on inhibitors of cd9, akt and molecules of the tetraspanin signalling network. WO2013171777A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.5392 mL	12.6958 mL	25.3917 mL	63.4792 mL
	5 mM	0.5078 mL	2.5392 mL	5.0783 mL	12.6958 mL
	10 mM	0.2539 mL	1.2696 mL	2.5392 mL	6.3479 mL
H₂O	15 mM	0.1693 mL	0.8464 mL	1.6928 mL	4.2319 mL
	20 mM	0.1270 mL	0.6348 mL	1.2696 mL	3.1740 mL
	25 mM	0.1016 mL	0.5078 mL	1.0157 mL	2.5392 mL
	30 mM	0.0846 mL	0.4232 mL	0.8464 mL	2.1160 mL
	40 mM	0.0635 mL	0.3174 mL	0.6348 mL	1.5870 mL
	50 mM	0.0508 mL	0.2539 mL	0.5078 mL	1.2696 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.