1. PI3K/Akt/mTOR
  2. Akt
  3. AKT Kinase Inhibitor

AKT Kinase Inhibitor 

Cat. No.: HY-10249A Purity: 98.37%
Handling Instructions

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.

For research use only. We do not sell to patients.

AKT Kinase Inhibitor Chemical Structure

AKT Kinase Inhibitor Chemical Structure

CAS No. : 842148-40-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 720 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor:

Top Publications Citing Use of Products

Publications Citing Use of MCE AKT Kinase Inhibitor

    AKT Kinase Inhibitor purchased from MCE. Usage Cited in: Mediat Inflamm. 2020 Jun.

    After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

    View All Akt Isoform Specific Products:

    • Biological Activity

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    Description

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

    IC50 & Target[1]

    Akt

     

    In Vitro

    The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    357.37

    Formula

    C₁₆H₁₉N₇O₃

    CAS No.

    842148-40-7

    SMILES

    OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (46.65 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7982 mL 13.9911 mL 27.9822 mL
    5 mM 0.5596 mL 2.7982 mL 5.5964 mL
    10 mM 0.2798 mL 1.3991 mL 2.7982 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1.67 mg/mL (4.67 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    AKT Kinase InhibitorAktPKBProtein kinase BInhibitorinhibitorinhibit

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    Product Name:
    AKT Kinase Inhibitor
    Cat. No.:
    HY-10249A
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