1. PI3K/Akt/mTOR
  2. Akt
  3. AKT Kinase Inhibitor

AKT Kinase Inhibitor 

Cat. No.: HY-10249A Purity: 99.92%
COA Handling Instructions

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.

For research use only. We do not sell to patients.

AKT Kinase Inhibitor Chemical Structure

AKT Kinase Inhibitor Chemical Structure

CAS No. : 842148-40-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 462 In-stock
Solution
10 mM * 1 mL in DMSO USD 462 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 720 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor:

Top Publications Citing Use of Products

    AKT Kinase Inhibitor purchased from MedChemExpress. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261.  [Abstract]

    After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

    In Vitro

    The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    357.37

    Formula

    C16H19N7O3

    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (55.96 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7982 mL 13.9911 mL 27.9822 mL
    5 mM 0.5596 mL 2.7982 mL 5.5964 mL
    10 mM 0.2798 mL 1.3991 mL 2.7982 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.67 mg/mL (4.67 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

    References
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    AKT Kinase Inhibitor Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
    AKT Kinase Inhibitor
    Cat. No.:
    HY-10249A
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