1. PI3K/Akt/mTOR
  2. Akt
  3. AKT Kinase Inhibitor

AKT Kinase Inhibitor 

Cat. No.: HY-10249A Purity: 99.92%
COA Handling Instructions

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.

For research use only. We do not sell to patients.

AKT Kinase Inhibitor Chemical Structure

AKT Kinase Inhibitor Chemical Structure

CAS No. : 842148-40-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 462 In-stock
10 mM * 1 mL in DMSO USD 462 In-stock
5 mg USD 420 In-stock
10 mg USD 720 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor:

Top Publications Citing Use of Products

    AKT Kinase Inhibitor purchased from MedChemExpress. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261.  [Abstract]

    After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

    In Vitro

    The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight




    CAS No.



    White to light yellow




    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (55.96 mM; ultrasonic and warming and heat to 60°C)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7982 mL 13.9911 mL 27.9822 mL
    5 mM 0.5596 mL 2.7982 mL 5.5964 mL
    10 mM 0.2798 mL 1.3991 mL 2.7982 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.67 mg/mL (4.67 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

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    AKT Kinase Inhibitor Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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