AKT Kinase Inhibitor hydrochloride
Based on 18 publication(s) in Google Scholar
AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity : 99.23%
- CAS No.: 3026697-00-4
- Formula: C16H20ClN7O3
- Molecular Weight:393.83
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AKT Kinase Inhibitor hydrochloride
More- Cell. 2026 Jun 11;189(12):3541-3552.e18. [Abstract]
- Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9. [Abstract]
- Cell Death Dis. 2024 Nov 9;15(11):809. [Abstract]
- Pharmacol Res. 2024 Jun:204:107218. [Abstract]
- Small. 2023 Apr;19(16):e2207194. [Abstract]
- Int J Biol Sci. 2024 Apr 29;20(7):2748-2762. [Abstract]
- Cell Commun Signal. 2022 Mar 19;20(1):35. [Abstract]
- Phytother Res. 2022 Apr;36(4):1724-1735. [Abstract]
- Cell Rep. 2023 May 23;42(6):112547. [Abstract]
- Transl Psychiatry. 2026 Apr 1;16(1):275. [Abstract]
- Life Sci. 2019 Aug 15:231:116554. [Abstract]
- Inflammation. 2021 Jun;44(3):890-898. [Abstract]
- Biofactors. 2025 May-Jun;51(3):e70023. [Abstract]
- Mediators Inflamm. 2020 Jun 24:2020:3621261. [Abstract]
- J Cancer. 2021 May 5;12(13):3809-3818. [Abstract]
- Research Square Preprint. 2023 May 26.
- Oxid Med Cell Longev. 2021 Mar 19:2021:5595376. [Abstract]
- Research Square Preprint. 2020 Dec.
Customer Validation & Images
-
WB
-
RT-PCR
-
WB
-
IF
-
Cell Migration/Invasion Assay
Biological Activity
Description
In Vitro
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3026697-00-4
-
Appearance Solid
-
Molecular Weight 393.83
-
Formula C16H20ClN7O3
-
Color Off-white to light yellow
-
SMILES
OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (18)
-
Journal Impact Factor
-
Most Recent
-
Cell
2026 Jun 11;189(12):3541-3552.e18. PMID: 41999746 -
Cell Stem Cell
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. [Abstract]2023 Apr 6;30(4):450-459.e9. PMID: 36944335
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9. [Abstract]
Immunofluorescence of LIN28A at the end of stage I under SI_BMP4/B27+AKTi (AKT Kinase Inhibitor: 1 μM) +VTP+J condition.
-
Cell Death Dis
Combined metformin and simvastatin therapy inhibits SREBP2 maturation and alters energy metabolism in glioma. [Abstract]2024 Nov 9;15(11):809. PMID: 39521788 -
Pharmacol Res
STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop. [Abstract]2024 Jun:204:107218. PMID: 38768671
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Jun:204:107218. [Abstract]
Stimulation of B16-F10 cells with TAM-conditioned medium, pre-treated with AKT Kinase Inhibitor (5 μM) for 24 h. Western blot assessing AKT phosphorylation, AKT baseline expression, and STC1 expression.
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Jun:204:107218. [Abstract]
Stimulation of B16-F10 cells with TAM-conditioned medium, pre-treated with AKT kinase inhibitor (5 μM) for 24 h. CCL2 mRNA expression was detected by qPCR.
-
Small
2023 Apr;19(16):e2207194. PMID: 36634971
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Small. 2023 Apr;19(16):e2207194. [Abstract]
AKT Kinase Inhibitor (10 μM). Comparison of migration restriction ability of SK-Hep-1, SNU-449, PANC-1, SW1990 and primary cancer-associated fibroblasts.
-
Int J Biol Sci
Nuclear Softness Promotes the Metastatic Potential of Large-Nucleated Colorectal Cancer Cells via the ErbB4-Akt1-Lamin A/C Signaling Pathway. [Abstract]2024 Apr 29;20(7):2748-2762. PMID: 38725859
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2024 Apr 29;20(7):2748-2762. [Abstract]
Western blotting analysis of Akt1, p-Akt1 (Ser473), lamin A/C, and p-lamin A/C (Ser22) in SW480 LNCs treated with or without AKT Kinase Inhibitor (Akti; 0.5 μM).
-
Cell Commun Signal
Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway. [Abstract]2022 Mar 19;20(1):35. PMID: 35305679 -
Phytother Res
Maltol mitigates cisplatin-evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro. [Abstract]2022 Apr;36(4):1724-1735. PMID: 35174550 -
Cell Rep
2023 May 23;42(6):112547. PMID: 37224020 -
Transl Psychiatry
Non-gene-edited neural stem cells reverse neuroinflammation and microbiota dysbiosis in a sprague-dawley rat model of autism spectrum disorder. [Abstract]2026 Apr 1;16(1):275. PMID: 41922322 -
Life Sci
Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway. [Abstract]2019 Aug 15:231:116554. PMID: 31194992 -
Inflammation
Tadalafil Alleviates LPS-Induced Inflammation and Oxidative Stress of RWPE-1 Cell by Regulating the Akt/Nrf2 Signaling Pathway. [Abstract]2021 Jun;44(3):890-898. PMID: 33398543 -
Biofactors
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways. [Abstract]2025 May-Jun;51(3):e70023. PMID: 40411279 -
Mediators Inflamm
Secoisolariciresinol Diglucoside Exerts Anti-Inflammatory and Antiapoptotic Effects through Inhibiting the Akt/I κ B/NF- κ B Pathway on Human Umbilical Vein Endothelial Cells. [Abstract]2020 Jun 24:2020:3621261. PMID: 32684834
AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2020 Jun 24:2020:3621261. [Abstract]
After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.
-
J Cancer
YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. [Abstract]2021 May 5;12(13):3809-3818. PMID: 34093789 -
-
Oxid Med Cell Longev
A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion. [Abstract]2021 Mar 19:2021:5595376. PMID: 33828639 -
Solvent & Solubility
In Vitro:
H2O : 20 mg/mL (50.78 mM; Need ultrasonic)
DMSO : 5.88 mg/mL (14.93 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5392 mL | 12.6958 mL | 25.3917 mL | 63.4792 mL |
| 5 mM | 0.5078 mL | 2.5392 mL | 5.0783 mL | 12.6958 mL | |
| 10 mM | 0.2539 mL | 1.2696 mL | 2.5392 mL | 6.3479 mL | |
| H2O | 15 mM | 0.1693 mL | 0.8464 mL | 1.6928 mL | 4.2319 mL |
| 20 mM | 0.1270 mL | 0.6348 mL | 1.2696 mL | 3.1740 mL | |
| 25 mM | 0.1016 mL | 0.5078 mL | 1.0157 mL | 2.5392 mL | |
| 30 mM | 0.0846 mL | 0.4232 mL | 0.8464 mL | 2.1160 mL | |
| 40 mM | 0.0635 mL | 0.3174 mL | 0.6348 mL | 1.5870 mL | |
| 50 mM | 0.0508 mL | 0.2539 mL | 0.5078 mL | 1.2696 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AKT Kinase Inhibitor hydrochloride Related Classifications
HY-10249D Related Classifications
Powered by Bioz