1. PI3K/Akt/mTOR
  2. Akt
  3. AKT Kinase Inhibitor hydrochloride

AKT Kinase Inhibitor hydrochloride 

Cat. No.: HY-10249D Purity: 99.24%
COA Handling Instructions

AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

AKT Kinase Inhibitor hydrochloride Chemical Structure

AKT Kinase Inhibitor hydrochloride Chemical Structure

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 462 Get quote
Solution
10 mM * 1 mL in Water USD 462 Get quote
Solid
5 mg USD 420 In-stock
10 mg USD 720 In-stock
25 mg USD 1500 In-stock
50 mg USD 2400 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of AKT Kinase Inhibitor hydrochloride:

Top Publications Citing Use of Products

    AKT Kinase Inhibitor hydrochloride purchased from MedChemExpress. Usage Cited in: Mediat Inflamm. 2020 Jun 24;2020:3621261.  [Abstract]

    After treatment with HY-10249A, the expression of p-IκB-α and p-NF-κB p65 is reduced.

    View All Akt Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    AKT Kinase Inhibitor hydrochloride is an Akt kinase inhibitor with anti-tumor activity[1]. AKT Kinase Inhibitor (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

    In Vitro

    The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    393.83

    Formula

    C16H20ClN7O3

    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 20 mg/mL (50.78 mM; Need ultrasonic)

    DMSO : 3.33 mg/mL (8.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5392 mL 12.6958 mL 25.3917 mL
    5 mM 0.5078 mL 2.5392 mL 5.0783 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.24%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 2.5392 mL 12.6958 mL 25.3917 mL 63.4792 mL
    5 mM 0.5078 mL 2.5392 mL 5.0783 mL 12.6958 mL
    H2O 10 mM 0.2539 mL 1.2696 mL 2.5392 mL 6.3479 mL
    15 mM 0.1693 mL 0.8464 mL 1.6928 mL 4.2319 mL
    20 mM 0.1270 mL 0.6348 mL 1.2696 mL 3.1740 mL
    25 mM 0.1016 mL 0.5078 mL 1.0157 mL 2.5392 mL
    30 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL
    40 mM 0.0635 mL 0.3174 mL 0.6348 mL 1.5870 mL
    50 mM 0.0508 mL 0.2539 mL 0.5078 mL 1.2696 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    AKT Kinase Inhibitor hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    AKT Kinase Inhibitor hydrochloride
    Cat. No.:
    HY-10249D
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