ALD-52  (Synonyms: 1-Acetyl-LSD)

ALD-52 (1-Acetyl-LSD) is a prodrug for LSD. ALD-52 shows an affinity to 5-HT_1A, 5-HT_2A and 5-HT_2C with a sub>D values of 1054, 174 and 10.2 nM, respectively. ALD-52 is converted to LSD and induces a head-twitch response (HTR) in vivo. ALD-52 can be used for hallucinogen research^[1].

ALD-52 shows an affinity to 5-HT_1A, 5-HT_2A and 5-HT_2C with a sub>D values of 1054, 174 and 10.2 nM, respectively^[1].
ALD-52 acts as very weak partial agonists at the human 5-HT_2A receptor with an EC₅₀ value of 38 nM and an E_max value of 25%, shows slightly higher potency and efficacy at m5-HT_{2A< /sub> with an EC50 value of 12 nM and an Emax value of 19%, shows no agonist activity at h5-HT2B and h5-HT2C in HEK cell^[1].}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALD-52 induces head-twitch response (HTR) in C57BL/6J mice (6–8 weeks old) with an EC₅₀ value of 297.2 nM by by activating the 5-HT_2A receptor^[1].
ALD-52 (0.1-0.3 mg/kg, s.c., once) produces LSD plasma concentrations of 35.5 and 103.8 ng/mL in Sprague Dawley rats, respectively^[1].
ALD-52 (0.3 mg/kg, s.c., once) has biotransformation with multipathway and does not simply involve complete conversion to LSD (undergoes N deethylation, N6 demethylation, and hydroxylation, yielding two phenolic metabolites) in Sprague Dawley rats (consistent results were obtained using the in vitro human liver homogenate system.)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

365.47

C₂₂H₂₇N₃O₂

3270-02-8

[H][C@@]1(N(C)C[C@H](C(N(CC)CC)=O)C=C12)CC3=CN(C(C)=O)C4=C3C2=CC=C4

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• [1]. Halberstadt AL, et al .Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). Neuropharmacology. 2020 Aug 1;172:107856.  [Content Brief]

  [2]. Zhang SH, et al. Stability studies of ALD-52 and its homologue 1P-LSD. J Forensic Sci. 2023 May;68(3):1009-1019.  [Content Brief]