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  3. TNF Receptor IFNAR
  4. Anti-Mouse CD40L/CD154 Antibody (MR-1)

Anti-Mouse CD40L/CD154 Antibody (MR-1) 

製品番号: HY-P990134 純度: 99.62%
COA Technical Support

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量 価格（税別） 在庫状況 数量
1 mg $120 在庫あり
5 mg $430 在庫あり
10 mg $725 在庫あり
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100 mg   お問い合わせ  

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製品説明

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis[1][2][3].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD40L/CD154
体外実験

Anti-Mouse CD40L/CD154 Antibody (MR-1) (200 μg/mL, 48 h) significantly inhibits the production of IFN-β in natural killer T (NKT) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD40L/CD154 Antibody (MR-1) 関連抗体

ELISA Assay[1]

Cell Line: NKT cells, co-cultivation with peritoneal macrophages
Concentration: 200 μg/mL
Incubation Time: 48 h
Result: Reduced the level of IFN-β.
体内実験

Anti-Mouse CD40L/CD154 Antibody (MR-1) (500 μg, i.p., once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation) significantly reduces the expression of type I IFN signaling pathway related genes in male C57BL/6J mice bearing KPC1242 tumors[1].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (20 mg/kg, i.p., once daily for 4 days at 1 day before surgery, once a week until the end of the experiment) extends the survival time of human neural stem cells (hNSCs) in 5XFAD transgenic mice[2].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (25 mg/kg, i.p., on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage) can temporarily delay the progression of cholangitis in dnTGFβRII mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×104 KPC1242 cells injected male C57BL/6J mice (8-12 weeks)[1]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation
Result: Significantly reduced the expression of IFN signaling pathway.
Animal Model: 5XFAD transgenic mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 days at 1 day before surgery, once a week until the end of the experiment
Result: Extended the survival time of hNSCs to 34 weeks.
Significantly suppressed transplant rejection reaction.
Animal Model: dnTGFβRII mice (3-4 weeks)[3]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage
Result: Significantly reduced portal vein inflammation and bile duct injury scores for short-term treatment.
Reduced intrahepatic NKT cells and effector T cells in short-term treatment.
Reduced the levels of IFN-γ, IL-4 and IL-17A for short-term treatment.
Gene ID

21947  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD40L/CD154 Antibody (MR-1)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Clinical disease scores of mice with active intestinal inflammation and upon Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) remission in colitis.
  • Histopathological scores of naive mice, mice with active disease, or Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) in colitis.
純度とドキュメンテーション

純度: 99.62%

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
参考文献
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Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40L/CD154 Antibody (MR-1)TNF ReceptorIFNARTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorCD40L/CD154IFNtransplantsKPC1242Inhibitorinhibitorinhibit

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製品名:
Anti-Mouse CD40L/CD154 Antibody (MR-1)
製品番号:
HY-P990134
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