2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse/Human IL-7 Antibody (M25)

Anti-Mouse/Human IL-7 Antibody (M25) 

製品番号: HY-P990210 純度: ≥95.0%
COA Technical Support

Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation.

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Anti-Mouse/Human IL-7 Antibody (M25)

Anti-Mouse/Human IL-7 Antibody (M25) 構造式

容量 価格（税別） 在庫状況 数量
1 mg $135 在庫あり
5 mg $495 在庫あり
10 mg $850 在庫あり
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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation[1][2].

Isotype

Mouse IgG2b kappa
Recommend Isotype Controls
Species Reactivity

Human/Mouse
IC50 & Target[1][2]

IL7R

 

体内実験

Anti-Mouse/Human IL-7 Antibody (M25) (500 μg/mouse, i.p., single dose, 3 h before Papain injection) significantly reduces eosinophil infiltration and alleviates inflammation in wild-type C57BL/6 mice with a Papain (HY-P1645) induced airway inflammation[1].
Anti-Mouse/Human IL-7 Antibody (M25) (3 mg, i.p., once every 3-4 days, for 2 weeks) significantly reduces the number of B cell precursors in NSG mice injected with CD34+ cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Papain (100 μg, intranasal injection, on day 0, 1, and 2 ) induced wild-type C57BL/6 mice (8-12 weeks)[1]
Dosage: 500 μg/mouse
Administration: Intraperitoneal injection (i.p.), single dose, 3 h before Papain injection
Result: Significantly reduced eosinophil infiltration.
Reduced the expression of ST2 in innate lymphoid cells (ILC2s).
Reduced the level of IL-5.
Animal Model: NSG mice injected with CD34+ cells[2]
Dosage: 3 mg
Administration: Intraperitoneal injection (i.p.), once every 3-4 days for 2 weeks
Result: Significantly reduced the number of B cell precursors in T mice (without hTSLP).
Gene ID

16196  [NCBI]

Accession

P10168 / Q544C8 / NP_032397.1
Application

in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation (as a complex with IL-7)
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human IL-7 Antibody (M25)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション

純度: ≥95.0%

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
参考文献
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Anti-Mouse/Human IL-7 Antibody (M25) Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human IL-7 Antibody (M25)Interleukin RelatedILIL-7ILC2sB cellairway inflammationInhibitorinhibitorinhibit

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製品名:
Anti-Mouse/Human IL-7 Antibody (M25)
製品番号:
HY-P990210
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