Il7 - interleukin 7 Gene

Also Known as Il-7; hlb368; A630026I06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16196

Summary

The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Il7 Products (4)

mRNA Protein Name
NM_001313888.1 NP_001300817.1 interleukin-7 isoform b
NM_001313889.1 NP_001300818.1 interleukin-7 isoform c
NM_001313890.1 NP_001300819.1 interleukin-7 isoform b
NM_008371.5 NP_032397.1 interleukin-7 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
12490655 MGI
enables growth factor activity IDA
IDA: Inferred from direct assay
12970760 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell proliferation IGI
IGI: Inferred from genetic interaction
7671324 MGI
acts upstream of or within T cell lineage commitment IMP
IMP: Inferred from mutant phenotype
9252127 MGI
acts upstream of or within bone resorption IDA
IDA: Inferred from direct assay
12490655 MGI
acts upstream of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10429671 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
9252127 MGI
acts upstream of or within negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
8950980 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10429671 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
8950980 MGI
acts upstream of organ growth IGI
IGI: Inferred from genetic interaction
9252127 MGI
acts upstream of organ growth IMP
IMP: Inferred from mutant phenotype
9252127 MGI
acts upstream of or within positive regulation of B cell differentiation IDA
IDA: Inferred from direct assay
16797412 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
12970760 MGI
acts upstream of or within positive regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
7671324 MGI
acts upstream of or within positive regulation of T cell differentiation IDA
IDA: Inferred from direct assay
12431371 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
16797412 MGI
acts upstream of or within positive regulation of organ growth IGI
IGI: Inferred from genetic interaction
9252127 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: Inferred from mutant phenotype
9252127 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
8950980 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
9252127 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
29581031 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8950980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-7

Recombinant Il7 Proteins

Cat. No. Product Name Accession Purity
HY-P7082 IL-7 Protein, Mouse (CHO, His) P10168/Q544C8/NP_032397.1 (E26-I154) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70566 IL-7 Protein, Mouse (HEK293, His) P10168/Q544C8/NP_032397.1 (E26-I154) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73226 IL-7 Protein, Mouse P10168/Q544C8/NP_032397.1 (E26-I154) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700217AF Animal-Free IL-7 Protein, Mouse (His) P10168/Q544C8/NP_032397.1 (E26-I154) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99412 Lusvertikimab Antagonist 99.41% Phase 2
HY-P990023 Bempikibart Antagonist 98.00% Phase 2
HY-P99908 Efineptakin alfa Activator 99.70% Phase 2
HY-P991424 GSK2618960 Inhibitor 95.66% Phase 2
HY-P990647 PF-06342674 Inhibitor 99.69% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-206870 BP79 Inhibitor / Unkown
HY-167153 PNA5 / Unkown
HY-RS06779 IL7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06780 IL7R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174597 Human IL7R mRNA / Unkown
HY-174598 Human IL7 mRNA / Unkown
HY-RS16894 Il7r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17031 Il7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23336 Il7r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23475 Il7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990774 Verekitug Inhibitor 97.00% Unkown
HY-P990210 Anti-Mouse/Human IL-7 Antibody (M25) Inhibitor 98.43% Unkown
HY-P990911 Crebankitug Inhibitor ≥99.0% Unkown
HY-P990209 Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) Inhibitor 95.00% Unkown
HY-P991720 Tepilukimig Inhibitor 95.57% Unkown
HY-P990292 Anti-Mouse CD132 (common γ chain) Antibody (3E12) Inhibitor / Unkown
HY-P991265 OSE-703 Inhibitor / Unkown
HY-P992447 QX008N Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il7 NCBI NCBI:3574