Anti-Mouse/Human IL-7 Antibody (M25)
Based on 1 publication(s) in Google Scholar
Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation.
For research use only. We do not sell to patients.
- Purity: 98.43%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse/Human IL-7 Antibody (M25)
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Biological Activity
Description
Isotype
Mouse IgG2b kappa
Recommend Isotype Controls
Species Reactivity
Human/Mouse
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IL7R |
In Vivo
Anti-Mouse/Human IL-7 Antibody (M25) (3 mg, i.p., once every 3-4 days, for 2 weeks) significantly reduces the number of B cell precursors in NSG mice injected with CD34+ cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Papain (100 μg, intranasal injection, on day 0, 1, and 2 ) induced wild-type C57BL/6 mice (8-12 weeks)[1]
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Dosage:500 μg/mouse
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Administration:Intraperitoneal injection (i.p.), single dose, 3 h before Papain injection
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Result:Significantly reduced eosinophil infiltration.
Reduced the expression of ST2 in innate lymphoid cells (ILC2s).
Reduced the level of IL-5.
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Animal Model:NSG mice injected with CD34+ cells[2]
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Dosage:3 mg
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Administration:Intraperitoneal injection (i.p.), once every 3-4 days for 2 weeks
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Result:Significantly reduced the number of B cell precursors in T mice (without hTSLP).
Gene ID
Accession
P10168 / Q544C8 / NP_032397.1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation (as a complex with IL-7)
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse/Human IL-7 Antibody (M25)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Stem Cell Res Ther
Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway. [Abstract]2025 May 1;16(1):217. PMID: 40312752
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Takami D, et al. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. Int Immunol. 2023 Nov 7;35(11):513-530. [Content Brief]
[2]. Milford TA, et al. TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis. Eur J Immunol. 2016 Sep;46(9):2155-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse/Human IL-7 Antibody (M25) Related Classifications
HY-P990210 Related Classifications
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