Efineptakin alfa
Based on 1 Customer Validation
Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 2026634-47-7
- Molecular Weight:90.96 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL7R |
Efineptakin alfa (10 mg/kg) mitigates RT-related lymphopenia, increases cytotoxic CD8 T lymphocytes systemically and in the tumor, and improves survival in orthotopic glioma-bearing mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice bearing intracranial tumors (GL261 or CT2A)[1]
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Dosage:10 mg/kg
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Administration:On the final day of RT (radiotherapy, 1.8 Gy/day × 5 days) completion
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Result:Increased T lymphocytes in the lymph nodes, thymus, and spleen, enhanced IFNγ production, and decreased Tregs in the tumor which was associated with a significant increase in survival. Enhanced central memory and effector memory CD8 T cells in lymphoid organs and tumor. Decreased progenitor cells in the bone marrow.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[IL7 (interleukin 7, IL-7)]1-IGHG4 Fc (Fragment constant)
ELISA, FACS, Functional assay
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Immobilized CD127/IL-7RA Protein, Human can bind Efineptakin alfa. The EC50 for this effect is 12.04 ng/mL.
Chemical Information
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CAS No. 2026634-47-7
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Appearance Liquid
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Molecular Weight 90.96 kDa
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Color Colorless to light yellow
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SMILES
[Efineptakin alfa]
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Synonyms
NT-17
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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