2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse TNFR2 Antibody (TR75-54.7)

Anti-Mouse TNFR2 Antibody (TR75-54.7) 

Cat. No.: HY-P99149 Pureza: 98.864%
COA
SDS
Technical Support

Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse TNFR2 IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Anti-Mouse TNFR2 Antibody (TR75-54.7)

Anti-Mouse TNFR2 Antibody (TR75-54.7) Estructura química

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg En stock
10 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Anti-Mouse TNFR2 Antibody (TR75-54.7) Recomendaciones destacadas:

Anti-Mouse TNFR2 Antibody (TR75-54.7) Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas TNF Receptor:

Ver todas las isoformas
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Anti-Mouse TNFR2 Antibody (TR75-54.7) is an anti-mouse TNFR2 IgG monoclonal antibody. Anti-Mouse TNFR2 Antibody (TR75-54.7) can reduce white blood cell count (WBC) and decrease the expression of some pro-inflammatory cytokines such as CCL2 and CXCL5. Anti-Mouse TNFR2 Antibody (TR75-54.7) can be used for researches on inflammation conditions and cancer such as breast cancer[1][2].

Isotype

Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

TNFR2
In Vivo

Anti-Mouse TNFR2 Antibody (TR75-54.7) (200 μg, i.p., single dose, 3 days before inoculation of 4T1 tumor cells) significantly inhibits tumor growth and prolong survival in female wild-type Balb/c mice bearing 4T1 tumors[1].
Anti-Mouse TNFR2 Antibody (TR75-54.7) (5 mg/kg, i.p., twice weekly, for 3 weeks) significantly reduces white blood cell count (WBC) and downregulates some pro-inflammatory cytokines in JAK2+/VF knock-in C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×105 4T1 cells injected female wild-type Balb/c mice (8-12 weeks)[1]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), single dose, 3 days before inoculation of 4T1 tumor cells
Result: Significantly prolonged the survival period of mice.
Significantly inhibited tumor volume.
Animal Model: JAK2+/VF knock-in C57BL/6 mice[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), twice weekly, for 3 weeks
Result: Significantly reduced white blood cell count (WBC), but did not significantly improve hematocrit (HCT), hemoglobin (HGB), and splenomegaly.
Downregulated some pro-inflammatory cytokines such as CCL2 and CXCL5, but upregulated other inflammatory markers such as CXCL2 and IL-12.
Gene ID

21938  [NCBI]

Accession
Application

in vivo TNFR2 blockade; in vitro TNFR2 blockade
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TNFR2 Antibody (TR75-54.7)]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación

Purity: 98.864%

SDS (251 KB)

COA (232 KB) SDS-PAGE (67 KB) SEC-HPLC (165 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse TNFR2 Antibody (TR75-54.7) Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TNFR2 Antibody (TR75-54.7)TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFR2inflammationcancer4T1Inhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Anti-Mouse TNFR2 Antibody (TR75-54.7)
Cat. No.:
HY-P99149
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.