2. GPCR/G Protein
  3. P2Y Receptor
  4. AR-C118925XX

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth.

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AR-C118925XX

AR-C118925XX Estructura química

No. CAS : 216657-60-2

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 3 publication(s) in Google Scholar

AR-C118925XX Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas P2Y Receptor:

Ver todas las isoformas
P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • Actividad biológica

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  • Referencias

  • Revisión del cliente

Descripciòn

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].

IC50 & Target[1]

P2Y2 Receptor

 

In Vivo

AR-C118925XX (i.p.) suppresses Bleomycin-enhanced dermal thickness in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

537.59

Fòrmula

C28H23N7O3S
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(CN2C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C53)C(NC2=O)=S)O1)NC6=NN=NN6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (186.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8602 mL 9.3008 mL 18.6015 mL
5 mM 0.3720 mL 1.8602 mL 3.7203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (4.65 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (4.65 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación

Purity: ≥99.0%

SDS (544 KB)

COA (254 KB) Elemental Analysis Report (112 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8602 mL 9.3008 mL 18.6015 mL 46.5038 mL
5 mM 0.3720 mL 1.8602 mL 3.7203 mL 9.3008 mL
10 mM 0.1860 mL 0.9301 mL 1.8602 mL 4.6504 mL
15 mM 0.1240 mL 0.6201 mL 1.2401 mL 3.1003 mL
20 mM 0.0930 mL 0.4650 mL 0.9301 mL 2.3252 mL
25 mM 0.0744 mL 0.3720 mL 0.7441 mL 1.8602 mL
30 mM 0.0620 mL 0.3100 mL 0.6201 mL 1.5501 mL
40 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1626 mL
50 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9301 mL
60 mM 0.0310 mL 0.1550 mL 0.3100 mL 0.7751 mL
80 mM 0.0233 mL 0.1163 mL 0.2325 mL 0.5813 mL
100 mM 0.0186 mL 0.0930 mL 0.1860 mL 0.4650 mL
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AR-C118925XX Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR-C118925XX216657-60-2P2Y ReceptorInhibitorinhibitorinhibit

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Nombre del producto:
AR-C118925XX
Cat. No.:
HY-110126
Cantidad:
MCE Japan Authorized Agent:

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