2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. ARQ 621

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity. ARQ 621 is a kinesin inhibitor. ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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ARQ 621

ARQ 621 構造式

CAS 番号 : 1095253-39-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 219 在庫あり
Solution
10 mM * 1 mL in DMSO USD 219 在庫あり
Solid
1 mg $70 在庫あり
5 mg $180 在庫あり
10 mg $260 在庫あり
25 mg $460 在庫あり
50 mg $660 在庫あり
100 mg $950 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

ARQ 621 関連抗体

Top Publications Citing Use of Products

Kinesin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14 Kinesin-13

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity[1]. ARQ 621 is a kinesin inhibitor[2]. ARQ 621 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Eg5

 

体外実験

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARQ 621 関連抗体
臨床実験
分子量

552.43

分子式

C28H24Cl2FN5O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CCCN)[C@@H](C(N1NC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC#C)C4=CC=CC(Cl)=C4F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 110 mg/mL (199.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8102 mL 9.0509 mL 18.1018 mL
5 mM 0.3620 mL 1.8102 mL 3.6204 mL
10 mM 0.1810 mL 0.9051 mL 1.8102 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: ≥99.0%

COA (259 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8102 mL 9.0509 mL 18.1018 mL 45.2546 mL
5 mM 0.3620 mL 1.8102 mL 3.6204 mL 9.0509 mL
10 mM 0.1810 mL 0.9051 mL 1.8102 mL 4.5255 mL
15 mM 0.1207 mL 0.6034 mL 1.2068 mL 3.0170 mL
20 mM 0.0905 mL 0.4525 mL 0.9051 mL 2.2627 mL
25 mM 0.0724 mL 0.3620 mL 0.7241 mL 1.8102 mL
30 mM 0.0603 mL 0.3017 mL 0.6034 mL 1.5085 mL
40 mM 0.0453 mL 0.2263 mL 0.4525 mL 1.1314 mL
50 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9051 mL
60 mM 0.0302 mL 0.1508 mL 0.3017 mL 0.7542 mL
80 mM 0.0226 mL 0.1131 mL 0.2263 mL 0.5657 mL
100 mM 0.0181 mL 0.0905 mL 0.1810 mL 0.4525 mL
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ARQ 621 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARQ 6211095253-39-6ARQ621ARQ-621KinesinEg5microtubulemotorproteincelldivisionAnti-tumorkinesinInhibitorinhibitorinhibit

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製品名:
ARQ 621
製品番号:
HY-16062
数量:
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