2. Protein Tyrosine Kinase/RTK
  3. Ephrin Receptor
  4. AWL-II-38.3

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf.

Para uso exclusivo en investigación. No vendemos a pacientes.

AWL-II-38.3

AWL-II-38.3 Estructura química

No. CAS : 1135205-94-5

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

AWL-II-38.3 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Ephrin Receptor:

Ver todas las isoformas
EphB EphA

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

IC50 & Target

Ephrin-A receptor (EphA3) kinase[1][2]
In Vitro

AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AWL-II-38.3 Related Antibodies
Peso molecular

469.42

Fòrmula

C23H18F3N5O3
No. CAS
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=NO1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C=NC(C)=C4)=C3)=O)=CC=C2C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : ≥ 100 mg/mL (213.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1303 mL 10.6514 mL 21.3029 mL
5 mM 0.4261 mL 2.1303 mL 4.2606 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1303 mL 10.6514 mL 21.3029 mL 53.2572 mL
5 mM 0.4261 mL 2.1303 mL 4.2606 mL 10.6514 mL
10 mM 0.2130 mL 1.0651 mL 2.1303 mL 5.3257 mL
15 mM 0.1420 mL 0.7101 mL 1.4202 mL 3.5505 mL
20 mM 0.1065 mL 0.5326 mL 1.0651 mL 2.6629 mL
25 mM 0.0852 mL 0.4261 mL 0.8521 mL 2.1303 mL
30 mM 0.0710 mL 0.3550 mL 0.7101 mL 1.7752 mL
40 mM 0.0533 mL 0.2663 mL 0.5326 mL 1.3314 mL
50 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0651 mL
60 mM 0.0355 mL 0.1775 mL 0.3550 mL 0.8876 mL
80 mM 0.0266 mL 0.1331 mL 0.2663 mL 0.6657 mL
100 mM 0.0213 mL 0.1065 mL 0.2130 mL 0.5326 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AWL-II-38.3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AWL-II-38.31135205-94-5Ephrin ReceptorEphA3LIMK2LIMK1ATPInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
AWL-II-38.3
Cat. No.:
HY-18832
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.