β-Cryptoxanthin  (Synonyms: (3R)-β-Cryptoxanthin)

β-Cryptoxanthin ((3R)-β-Cryptoxanthin) is an orally active carotenoid found in fruits and vegetables such as angerines, red peppers, and pumpkin. β-Cryptoxanthin inhibits prevents osteoclast formation and inhibits bone resorption. β-Cryptoxanthin maintains retinol status in vivo. β-cryptoxanthin shows anti-inflammation and anticancer activity. β-Cryptoxanthin can be used for the researches of osteoporosis and bladder carcer^[1][2].

β-Cryptoxanthin inhibits growth, upregulates RARβ mRNA, and transactivates RARE-mediated transcription in BEAS-2B lung epithelial cells in vitro^[1].
β-Cryptoxanthin increase calcium content,
protein content, and alkaline phosphatase activity in bone^[1].
β-Cryptoxanthin inhibits bone resorption in vitro by preventing osteoclast formation in mouse marrow cultures and inducing caspase-3-dependent apoptosis of mature osteoclastic cells, with synergistic effects alongside zinc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Cryptoxanthin (diet) from maize or fruit maintains retinol status in Mongolian gerbils at levels equivalent to β-carotenerich counterparts^[1].
β-cryptoxanthin supplementation significantly decreases smoke-induced
squamous metaplasia and inflammation in the lung and lowers tumor necrosis factor a concentrations in lung tissue cells and macrophages in ferrets^[1].
β-cryptoxanthin supplementation inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice, while restoring key regulatory gene expression and improving survival^[1].
β-cryptoxanthin supplementation inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice^[1].
β-Cryptoxanthin (50-500 µg/kg; p.o.; daily; 1 week) increases bone formation markers and prevents bone loss in multiple rat models of osteoporosis, with enhanced efficacy when combined with zinc^[1].
β-Cryptoxanthin (0.05-1.75 mg/kg; p.o.; ad libitum in drinking water; 7 days) dose-dependently suppresses psychosocial stress-induced adrenal hypertrophy in male ddY mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

552.87

C₄₀H₅₆O

472-70-8

Solid

Red to dark red

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C)=C(C)CCC1

Room temperature in continental US; may vary elsewhere.

• [1]. Burri BJ, et al. Absorption, metabolism, and functions of β-cryptoxanthin. Nutr Rev. 2016;74(2):69-82.  [Content Brief]

  [2]. Unno K, et al. Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on Females. Biol Pharm Bull. 2019;42(8):1402-1408.  [Content Brief]