2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Bremelanotide

Bremelanotide  (Synonyms: PT-141)

製品番号: HY-18678 純度: 99.69%
COA 取扱説明書 Technical Support

Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders.

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Bremelanotide

Bremelanotide 構造式

CAS 番号 : 189691-06-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 74 在庫あり
Solution
10 mM * 1 mL in Water USD 74 在庫あり
Solid
5 mg $42 在庫あり
10 mg $66 在庫あり
25 mg $132 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of Bremelanotide:

Bremelanotide 関連抗体

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Melanocortin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MC1R MC3R MC2R MC4R MC5R

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製品説明

Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders[1][2][3].

IC50 & Target[3]

MC4R

 

MC3R

 

体外実験

Bremelanotide (10−3-105 nM) binds to MC3R and MC4R in a concentration-dependent manner[3].
Bremelanotide induces cAMP accumulation in cell-free assays with EC50 values of 0.4 nM for MC3R and 0.2 nM for MC4R[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bremelanotide 関連抗体
体内実験

Bremelanotide (50-200 μg/kg; s.c.) selectively increases appetitive sexual behaviors (solicitations, hops and darts) in hormone-primed ovariectomized female rats via activation of MC4R and dopamine release in the medial preoptic area[1].
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)[1]
Dosage: 50, 100, 200 μg/kg
Administration: Subcutaneously injection
Result: Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Increased solicitations in estradiol-alone primed rats at 200 μg/kg.
Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Induced female mounting behavior at 200 μg/kg.
分子量

1025.16

分子式

C50H68N14O10
CAS 番号
Appearance

Solid

Color

White to off-white

輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (97.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9755 mL 4.8773 mL 9.7546 mL
5 mM 0.1951 mL 0.9755 mL 1.9509 mL
10 mM 0.0975 mL 0.4877 mL 0.9755 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.69%

COA (253 KB) RP-HPLC (110 KB) MS (222 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9755 mL 4.8773 mL 9.7546 mL 24.3864 mL
5 mM 0.1951 mL 0.9755 mL 1.9509 mL 4.8773 mL
10 mM 0.0975 mL 0.4877 mL 0.9755 mL 2.4386 mL
15 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
20 mM 0.0488 mL 0.2439 mL 0.4877 mL 1.2193 mL
25 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
30 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8129 mL
40 mM 0.0244 mL 0.1219 mL 0.2439 mL 0.6097 mL
50 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.4877 mL
60 mM 0.0163 mL 0.0813 mL 0.1626 mL 0.4064 mL
80 mM 0.0122 mL 0.0610 mL 0.1219 mL 0.3048 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bremelanotide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bremelanotide189691-06-3PT-141PT141PT 141Melanocortin ReceptorMC Receptormelanocortin receptorMC2RMC4Rhypoactive sexual desire disordersInhibitorinhibitorinhibit

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