2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 11 hydrochloride

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CCR1 antagonist 11 hydrochloride

CCR1 antagonist 11 hydrochloride Chemical Structure

Size Stock
50 mg   Obtenir un devis  
100 mg   Obtenir un devis  
250 mg   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

CCR1 antagonist 11 hydrochloride Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform CCR:

Voir toutes les isoformes
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • Activité biologique

  • Pureté et documentation

  • Références

  • Avis client

Description

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].

IC50 & Target

IC50: 0.03 μM (hCCR1)，0.58 μM (mCCR1), 0.32 μM (rCCR1)[1].
In Vitro

CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca2+ mobilization in THP-1 cells with the IC50 value of 1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCR1 antagonist 11 hydrochloride Related Antibodies
In Vivo

The pharmacokinetic parameters of CCR1 antagonist 11 hydrochloride(A1B1) in rat

Parameters PO (60 mg/kg)
t1/2 (h) 16.5
Cmax (μM/L) 0.85
AUC (h*ng/mL) 784
F (%) 95

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

466.38

Formule

C23H26Cl2FN3O2
SMILES

C[C@@H]1CN(CCN1C(/C=C/C2=C(NC(C)=O)C=C(Cl)C=C2)=O)CC3=CC=C(F)C=C3.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CCR1 antagonist 11 hydrochloride Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 11CCRCC chemokine receptorCCR1hCCR1mCCR1rCCR1rheumatoid arthritisInhibitorinhibitorinhibit

Vos produits récemment consultés:

Demande en ligne

Your information is safe with us. * Required Fields.

Nom du produit

  

Requested Quantity *

Nom du demandeur *

 

Civilité

Adresse e-mail *

 

Numéro de téléphone *

Department

 

Nom de l'organisation *

City

État

Country or Region *

      

Remarques

Bulk Inquiry

Inquiry Information

Nom du produit:
CCR1 antagonist 11 hydrochloride
Cat. No.:
HY-114097A
Quantité:
MCE Japan Authorized Agent:

Avis client

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nom du produit

  

Lot #

Nom du demandeur *

 

Adresse e-mail *

Numéro de téléphone

 

Department *

Nom de l'organisation *

 

Country or Region *

Remarques

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.