2. Anti-infection
  3. HIV
  4. Cyclotriazadisulfonamide

Cyclotriazadisulfonamide  (Synonyms: CADA)

Cat. No.: HY-134809 Purity: 98.45%
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Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor.

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Cyclotriazadisulfonamide

Cyclotriazadisulfonamide 화학구조

CAS No. : 182316-44-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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고객리뷰

Based on 1 Customer Validation

Other Forms of Cyclotriazadisulfonamide:

Cyclotriazadisulfonamide Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor[1][2][3].

IC50 & Target

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
HEK-293T IC50
0.38 μM
Compound: CADA
Inhibition of GFP-tagged Sortilin (unknown origin) expressed in HEK293T cells after 42 hrs by FACS analysis
Inhibition of GFP-tagged Sortilin (unknown origin) expressed in HEK293T cells after 42 hrs by FACS analysis
[PMID: 32209293]
SUP-T1 IC50
0.21 μM
Compound: CADA
Inhibition of FITC-tagged human CD4 expressed in human SUP-T1 cells after 72 hrs by FACS analysis
Inhibition of FITC-tagged human CD4 expressed in human SUP-T1 cells after 72 hrs by FACS analysis
[PMID: 32209293]
In Vitro

Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1].
Cyclotriazadisulfonamide (CADA) exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4+ T cells[1].
CADA prevents MT-4 cells from HIV-1 and SIV infection (EC50 are 0.7 and 1.2 g/ml, respectively)[1].
Cyclotriazadisulfonamide is a Sec61 translocon inhibitor with a selective nature. A proteomics study on T-cells is performed and identified only five substrates (huCD4, SORT, CD137, DNAJC3, PTK7, ERLEC1) for Cyclotriazadisulfonamide, with IC50s of 0.2–2 µM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclotriazadisulfonamide Related Antibodies

Western Blot Analysis[1]

Cell Line: MO-DCs.
Concentration: 0.4 μg/mL.
Incubation Time: 24 h.
Result: A 50% reduction in CD4 expression was obtained.
분자량

581.79

화학식

C31H39N3O4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1CC(CN(S(=O)(C2=CC=C(C)C=C2)=O)CCCN(CC3=CC=CC=C3)CCC1)=C)(C4=CC=C(C)C=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 33.33 mg/mL (57.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7188 mL 8.5942 mL 17.1883 mL
5 mM 0.3438 mL 1.7188 mL 3.4377 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7188 mL 8.5942 mL 17.1883 mL 42.9708 mL
5 mM 0.3438 mL 1.7188 mL 3.4377 mL 8.5942 mL
10 mM 0.1719 mL 0.8594 mL 1.7188 mL 4.2971 mL
15 mM 0.1146 mL 0.5729 mL 1.1459 mL 2.8647 mL
20 mM 0.0859 mL 0.4297 mL 0.8594 mL 2.1485 mL
25 mM 0.0688 mL 0.3438 mL 0.6875 mL 1.7188 mL
30 mM 0.0573 mL 0.2865 mL 0.5729 mL 1.4324 mL
40 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
50 mM 0.0344 mL 0.1719 mL 0.3438 mL 0.8594 mL
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Cyclotriazadisulfonamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclotriazadisulfonamide182316-44-5CADAHIVHuman immunodeficiency virusCD4ERInhibitorinhibitorinhibit

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상품명:
Cyclotriazadisulfonamide
Cat. No.:
HY-134809
수량:
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