Cyclotriazadisulfonamide hydrochloride
Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.
For research use only. We do not sell to patients.
- CAS No.: 392287-03-5
- Formula: C31H40ClN3O4S2
- Molecular Weight:618.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.56 μM
Compound: CADA
|
Downmodulation of human CD4 expressed in CHO cells transfected with CD4-YFP construct assessed as decrease in fluorescence intensity after 24 hrs by flow cytometry analysis
Downmodulation of human CD4 expressed in CHO cells transfected with CD4-YFP construct assessed as decrease in fluorescence intensity after 24 hrs by flow cytometry analysis
|
[PMID: 21800875] |
| HEK-293T | CC50 |
>50 μM
Compound: 1; CADA
|
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
|
[PMID: 34428050] |
| HEK-293T | IC50 |
2.2 μM
Compound: 1; CADA
|
Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis
Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis
|
[PMID: 34428050] |
| MT4 | CC50 |
>100 μM
Compound: 1; CADA
|
Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay
Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay
|
[PMID: 33181479] |
Chemical Information
-
CAS No. 392287-03-5
-
Molecular Weight 618.25
-
Formula C31H40ClN3O4S2
-
SMILES
O=S(C1=CC=C(C)C=C1)(N2CC(CN(S(=O)(C3=CC=C(C)C=C3)=O)CCCN(CCC2)CC4=CC=CC=C4)=C)=O.Cl
-
Synonyms
CADA hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclotriazadisulfonamide hydrochloride Related Classifications
HY-134809A Related Classifications
Powered by Bioz