2. Anti-infection
  3. HIV
  4. Cyclotriazadisulfonamide hydrochloride

Cyclotriazadisulfonamide hydrochloride  (Synonyms: CADA hydrochloride)

Cat. No.: HY-134809A
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Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.

For research use only. We do not sell to patients.

Cyclotriazadisulfonamide hydrochloride

Cyclotriazadisulfonamide hydrochloride Chemical Structure

CAS No. : 392287-03-5

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Cyclotriazadisulfonamide hydrochloride Related Antibodies

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Description

Cyclotriazadisulfonamide (CADA) hydrochloride is a specific CD4-targeted HIV entry inhibitor with activity against HIV-1 replication. Cyclotriazadisulfonamide hydrochloride can specifically downregulate the expression of CD4 receptors on the cell surface, effectively inhibiting HIV transmission. Cyclotriazadisulfonamide hydrochloride can inhibit HIV-1(NL4.3) and SIV(mac251), and has a synergistic effect when used in combination with cellulose acetate (CAP). Cyclotriazadisulfonamide hydrochloride can also be used as a microbial gel formulation to maintain CD4 downregulation and antiviral activity, and is a broad-spectrum anti-HIV agent.

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.56 μM
Compound: CADA
Downmodulation of human CD4 expressed in CHO cells transfected with CD4-YFP construct assessed as decrease in fluorescence intensity after 24 hrs by flow cytometry analysis
Downmodulation of human CD4 expressed in CHO cells transfected with CD4-YFP construct assessed as decrease in fluorescence intensity after 24 hrs by flow cytometry analysis
[PMID: 21800875]
HEK-293T CC50
> 50 μM
Compound: 1; CADA
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
[PMID: 34428050]
HEK-293T IC50
2.2 μM
Compound: 1; CADA
Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis
Down modulation of sortilin expression in HEK293T cells tranfected with GFP-tagged sortilin incubated for 24 hrs by flow cytometric analysis
[PMID: 34428050]
MT4 CC50
> 100 μM
Compound: 1; CADA
Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay
Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay
[PMID: 33181479]
Molecular Weight

618.25

Formula

C31H40ClN3O4S2
CAS No.
SMILES

O=S(C1=CC=C(C)C=C1)(N2CC(CN(S(=O)(C3=CC=C(C)C=C3)=O)CCCN(CCC2)CC4=CC=CC=C4)=C)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclotriazadisulfonamide hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclotriazadisulfonamide392287-03-5CADAHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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