1. Anti-infection
  2. HIV
  3. Cyclotriazadisulfonamide

Cyclotriazadisulfonamide (Synonyms: CADA)

Cat. No.: HY-134809
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Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way.

For research use only. We do not sell to patients.

Cyclotriazadisulfonamide Chemical Structure

Cyclotriazadisulfonamide Chemical Structure

CAS No. : 182316-44-5

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Description

Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way[1][2].

In Vitro

Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1].
Cyclotriazadisulfonamide (CADA) exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4+ T cells[1].
CADA prevents MT-4 cells from HIV-1 and SIV infection (EC50 are 0.7 and 1.2 g/ml, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MO-DCs.
Concentration: 0.4 μg/mL.
Incubation Time: 24 h.
Result: A 50% reduction in CD4 expression was obtained.
Molecular Weight

581.79

Formula

C₃₁H₃₉N₃O₄S₂

CAS No.
SMILES

O=S(N1CC(CN(S(=O)(C2=CC=C(C)C=C2)=O)CCCN(CC3=CC=CC=C3)CCC1)=C)(C4=CC=C(C)C=C4)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CyclotriazadisulfonamideCADAHIVHuman immunodeficiency virusCD4ERInhibitorinhibitorinhibit

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Cyclotriazadisulfonamide
Cat. No.:
HY-134809
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