2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP4Z1-IN-1

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CYP4Z1-IN-1

CYP4Z1-IN-1 構造式

CAS 番号 : 2760611-38-7

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

CYP4Z1-IN-1 関連抗体

Top Publications Citing Use of Products

Cytochrome P450 アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo[1].

IC50 & Target

CYP4Z1

41.8 ± 1.4 nM (IC50)

CYP4F11

291.3 ± 46 nM (IC50)

CYP4F12

1598.3 ± 5 nM (IC50)

CYP2D6

>10 000 nM (IC50)

CYP2C9

>10 000 nM (IC50)

CYP3A4

>10 000 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
483 nM
Compound: 7c
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36414390]
MDA-MB-231 IC50
483 nM
Compound: 7c
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 36414390]
体外実験

CYP4Z1-IN-1 (compound 7c) shows antiproliferative activity against breast CSCs (cancer stem cells), with an IC50 of 483 ± 2.5 nM[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24 h) suppresses the expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in breast cancer cells[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24-48 h) attenuates the migration and invasion ability of breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP4Z1-IN-1 関連抗体

Western Blot Analysis[1]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 0.8 μM, 3.2 μM, 12.8 μM, 51.2 μM
Incubation Time: 24 h
Result: Significantly suppressed the protein expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in MCF-7 cells in a concentration-dependent manner.
体内実験

CYP4Z1-IN-1 (compound 7c) (2000 mg/kg, orally, for 7 days) shows no evident toxicity and body weight loss in mice[1].
CYP4Z1-IN-1 (MCF-7 and MDA-MB-231 cells (12.8 μM, 72 h) implanted in the inguinal mammary gland of mice subcutaneously) blocks the tumor-initiating ability of breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 2000 mg/kg
Administration: orally, for 7 days
Result: Showed that compound 7c was rather safe; no evident toxicity and body weight loss were observed.
Animal Model: BALB/c-nude mice (3-4 week old, female)[1]
Dosage: 12.8 μM
Administration: MCF-7 and MDA-MB-231 cells were pre-treated with 7c (12.8 μM) for 72 h and were then implanted in the inguinal mammary gland of mice subcutaneously
Result: Blocked the tumor-initiating ability of breast cancer cells.
分子量

250.29

分子式

C13H18N2O3
CAS 番号
SMILES

O=C(CCCC1=CC=C(C=C1)N/C=N/O)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CYP4Z1-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP4Z1-IN-12760611-38-7Cytochrome P450CYPsCancer stem cellsCSCsMCF-7 cellsMDA-MB-231 cellsbreast cancerInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
CYP4Z1-IN-1
製品番号:
HY-152159
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.