dGTP  (Synonyms: 2'-Deoxyguanosine-5'-triphosphate)

dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP^[1][2].

dGTP can be hydrolyzed to deoxyguanosine and triphosphate by dGTP triphosphohydrolase in E. coli, which acts as a key factor in regulating the size of the dGTP pool^[1].
dGTP is oxidized to form 8-oxo-dGTP under the action of reactive oxygen species and other factors. During DNA replication, 8-oxo-dGTP can pair with C on the template strand, and also mispair with A. If it is incorporated into DNA without timely clearance, it will cause transversion mutations from A to C (or T to G), which is one of the main pathways of mutations induced by oxidative stress^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

507.18

C₁₀H₁₆N₅O₁₃P₃

2564-35-4

O[C@H]1C[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.  [Content Brief]

  [2]. Itsko M, et al. dGTP starvation in Escherichia coli provides new insights into the thymineless-death phenomenon. PLoS Genet. 2014;10(5):e1004310. Published 2014 May 8.  [Content Brief]