1. Membrane Transporter/Ion Channel
  2. EAAT2
  3. DL-TBOA

DL-TBOA 

Cat. No.: HY-107522 Purity: >99.0%
Handling Instructions

DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.

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DL-TBOA Chemical Structure

DL-TBOA Chemical Structure

CAS No. : 205309-81-5

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10 mM * 1 mL in DMSO USD 447 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively[1][2][3].

IC50 & Target

IC50: 70 μM (EAAT1), 6 μM (EAAT2) and 6 μM (EAAT3); Ki: 42 μM (human EAAT1), 5.7 μM (human EAAT2), 4.4 μM (EAAT4) and 3.2 μM (EAAT5)[1][2][3]

In Vitro

DL-TBOA (70-350 μM; 48 hours; HCT116 and LoVo cell lines) treatment concentration-dependently enhances SN38-induced loss of viability. DL-TBOA reversed Oxaliplatin-induced loss of viability[4].
DL-TBOA (350 μM; 24 hours; HCT116 and LoVo cell lines) treatment decreases p53 induction by SN38 and oxaliplatin[4].

Cell Viability Assay[4]

Cell Line: HCT116 and LoVo cell lines
Concentration: 70 μM or 350 μM
Incubation Time: 48 hours
Result: Enhanced SN38-induced, and counteracted Oxaliplatin-induced, cell death.

Cell Viability Assay[4]

Cell Line: HCT116 and LoVo cell lines
Concentration: 350 μM
Incubation Time: 24 hours
Result: p53 induction by SN38 and oxaliplatin was decreased.
Molecular Weight

239.22

Formula

C₁₁H₁₃NO₅

CAS No.

205309-81-5

SMILES

OC([[email protected]@H](N)[[email protected]@H](C(O)=O)OCC1=CC=CC=C1)=O.[Relative stereochemistry]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: >99.0%

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Keywords:

DL-TBOAEAAT2Excitatory amino acid transporter 2Glutamate transporter 1GLT-1Inhibitorinhibitorinhibit

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