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  3. Droloxifene

Droloxifene (Synonyms: 3-Hydroxytamoxifen)

Cat. No.: HY-121149 Purity: >98.0%
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Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats .

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Droloxifene Chemical Structure

Droloxifene Chemical Structure

CAS No. : 82413-20-5

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Estimated Time of Arrival: December 31
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Description

Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats [1][2][3].

In Vitro

Droloxifene (10 nM; 16-18 hours) induces apoptosis in MCF-7 cells[1].

Cell Viability Assay[2]

Cell Line: MCF-7 cells
Concentration: 10 nM
Incubation Time: 16-18 hours
Result: Induced cells apoptosis
In Vivo

Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day[3].

Animal Model: 5-month-old sham-operate rats[3]
Dosage: 5, 10, 20 mg/kg
Administration: Oral; daily for 4 weeks
Result: BMD of DFM increased significantly at 10mg/kg; completely prevented the decrease of BMC and BMD of DFM induced by OVX at 20 mg/kg/day.
Molecular Weight

387.51

Formula

C₂₆H₂₉NO₂

CAS No.

82413-20-5

SMILES

OC1=CC=CC(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Droloxifene3-HydroxytamoxifenEstrogen Receptor/ERRderivativeoralbreastcancerantiestrogenicimplantationboneovariectomizedInhibitorinhibitorinhibit

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Droloxifene
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HY-121149
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