EGFR-PK/JNK-2-IN-1

Cat. No.: HY-162332: Fiche technique Instruction de manipulation
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EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2 with IC₅₀s of 2.7 and 3.0 μM, respectively. EGFR-PK/JNK-2-IN-1 can induce apoptosis and induce cell cycle arrest at different cell phases. EGFR-PK/JNK-2-IN-1 can be used for the research of cancer.

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EGFR-PK/JNK-2-IN-1 Chemical Structure

CAS No. : 3034838-06-4

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This product is a controlled substance and not for sale in your territory.

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform EGFR:

Voir toutes les isoformes

EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

Voir tous les produits spécifiques à Isoform JNK:

Voir toutes les isoformes

JNK1 JNK2 JNK3 JNK

Activité biologique
Pureté et documentation
Références
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	29.8 3 Compound: 6c	Antiproliferative activity against human DLD-1 cells by WST-8 assay Antiproliferative activity against human DLD-1 cells by WST-8 assay	[PMID: 38408511]
K562	IC₅₀	15.4 3 Compound: 6c	Antiproliferative activity against human K562 cells by WST-8 assay Antiproliferative activity against human K562 cells by WST-8 assay	[PMID: 38408511]

Masse moléculaire

452.91

Formule

C₂₂H₁₇ClN₄O₃S

CAS No.

3034838-06-4

SMILES

ClC(C=C1)=CC=C1C2=CC(C(NC3=CC=C(S(=O)(N)=O)C=C3)=O)=NN2C4=CC=CC=C4

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Soltan OM, et al. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, moleecular docking, and bioactivity evaluation. Bioorg Med Chem Lett. 2024 Feb 24;102:129673. [Content Brief]

EGFR-PK/JNK-2-IN-1 Related Classifications

Calculateur de molarité
Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-PK/JNK-2-IN-13034838-06-4ApoptosisEGFRJNKEpidermal growth factor receptorErbB-1HER1c-Jun N-terminal kinaseapoptosiscell cycle arrestcancerInhibitorinhibitorinhibit

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