Enapotamab  (Synonyms: Anti-AXL/UFO Reference Antibody (enapotamab))

Enapotamab (Anti-AXL/UFO Reference Antibody) is an AXL/UFO-related antibody that can be used for synthesis of ADC molecule Enapotamab vedotin (HY-P99921)^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Enapotamab can be used as the ADC antibody of Enapotamab vedotin (HY-P99921).
Enapotamab vedotin exhibits cytotoxicity in AXL high expressing NSCLC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enapotamab vedotin exhibits antitumor efficacy against various NSCLC tumors with high AXL expression, also exhibits resistant to EGFR inhibitor in LU1868 xenograft mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

558  [NCBI]

P30530

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

143.895 kDa

1912423-61-0

Liquid

Colorless to light yellow

[Enapotamab]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Loaded Enapotamab on AHC2 biosensor, can bind AXL Protein, Human (449a.a, HEK293, His, HY-P74407) with an affinity constant of 6.653E-09 M as determined in BLI assay.
• 
  Immobilized AXL Protein, Human (HEK293, His, HY-P74407) can bind Enapotamab. The EC₅₀ for this effect is 0.3126 ng/mL.

• [1]. Matthew T. Burger, et al. Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof. WO2022115477A1.

  [2]. Koopman LA, et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199.  [Content Brief]