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Cat. No.: HY-P99921

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Enapotamab vedotin

Name: Enapotamab vedotin
Brand: MedChemExpress
SKU: HY-P99921
Availability: PreOrder

(Synonyms: HuMax-AXL-ADC)

Enapotamab vedotin is an AXL-targeted antibody-drug conjugate (ADC) with inhibitory potential against high AXL expressing non-small cell lung cancer (NSCLC). Enapotamab vedotin also exhibits resistant to EGFR inhibitor such as Osimertinib (HY-15772).

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CAS No.: 1912424-97-5

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (259 KB)

Enapotamab vedotin Chemical Structure

CAS No.: 1912424-97-5

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

AXL^[1]

Voir tous les produits spécifiques à Isoform TAM Receptor :

In Vitro

Enapotamab vedotin (0-10 μg/mL, 5 days) exhibits cytotoxicity in cells with high AXL expression such as ER20 and H1975-OR2, and reduces the cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[1]

View Protocol

Cell Line:

ER20, H1975-OR2
Concentration:

0-10 μg/mL
Incubation Time:

5 days
Result:

Reduced the cell viability.

In Vivo

Enapotamab vedotin (2-4 mg/kg, iv, once weekly for 2 doses) exhibits antitumor efficacy against various non-small cell lung cancer (NSCLC) with high AXL expression such as LU0395, exhibits resistant to EGFR inhibitor in LU1868 or LU0858 xenograft mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LU0395 xenograft mouse models^[1]
Dosage:

2-4 mg/kg
Administration:

iv, once weekly for 2 doses
Result:

Inhibited the tumor growth.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1912424-97-5
SMILES

[Enapotamab vedotin]
Synonyms

HuMax-AXL-ADC
Livraison

Shipping with dry ice.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Koopman LA, et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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