EP2 receptor antagonist-2

Name: EP2 receptor antagonist-2
Brand: MedChemExpress
SKU: HY-153129
Rating: 4.5 (0 reviews)

製品番号: HY-153129 純度: 99.32%: Data Sheet SDS COA 取扱説明書
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Technical Support

EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

EP2 receptor antagonist-2 構造式

CAS 番号 : 615273-95-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 143	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 143	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$130	在庫あり	Estimated Time of Arrival: December 31
10 mg	$210	在庫あり	Estimated Time of Arrival: December 31
25 mg	$360	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Prostaglandin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

DP EP FP IP TXA₂/TP TXB₂

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

体外実験

EP2 receptor antagonist-2 shows cytotoxicity against C6G cells with an CC₅₀ value of 575 μM^[1].
EP2 receptor antagonist-2 (20 μM; 30 min) decreases NMDA (30 µM)-induced LDH release in rat primary hippocampal neurons (DIV14)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

309.29

分子式

C₁₅H₁₄F₃N₃O

CAS 番号

615273-95-5

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=CC(C2=CC=CC=C2)=NC(N3CCOCC3)=N1)F

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (404.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2332 mL	16.1661 mL	32.3321 mL
5 mM	0.6466 mL	3.2332 mL	6.4664 mL
10 mM	0.3233 mL	1.6166 mL	3.2332 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.32%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (249 KB) HNMR (251 KB) RP-HPLC (260 KB) LCMS (95 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2332 mL	16.1661 mL	32.3321 mL	80.8303 mL
	5 mM	0.6466 mL	3.2332 mL	6.4664 mL	16.1661 mL
	10 mM	0.3233 mL	1.6166 mL	3.2332 mL	8.0830 mL
	15 mM	0.2155 mL	1.0777 mL	2.1555 mL	5.3887 mL
	20 mM	0.1617 mL	0.8083 mL	1.6166 mL	4.0415 mL
	25 mM	0.1293 mL	0.6466 mL	1.2933 mL	3.2332 mL
	30 mM	0.1078 mL	0.5389 mL	1.0777 mL	2.6943 mL
	40 mM	0.0808 mL	0.4042 mL	0.8083 mL	2.0208 mL
	50 mM	0.0647 mL	0.3233 mL	0.6466 mL	1.6166 mL
	60 mM	0.0539 mL	0.2694 mL	0.5389 mL	1.3472 mL
	80 mM	0.0404 mL	0.2021 mL	0.4042 mL	1.0104 mL
	100 mM	0.0323 mL	0.1617 mL	0.3233 mL	0.8083 mL