Eritoran tetrasodium  (Synonyms: E5564)

Eritoran tetrasodium (E5564) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity^[1][2].

Eritoran tetrasodium (233 μg/mouse; i.p.; 10 days) protects mouse from EBOV lethal infection, results 70% survived until the end of the study^[1].
Eritoran tetrasodium (2 μL of 1.1 mg/mL, corneal infusion) inhibits LPS (HY-D1056) -induced corneal inflammation in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1401.58

C₆₆H₁₂₂N₂Na₄O₁₉P₂

185954-98-7

CCCCCCC[C@@H](OC)CCO[C@@H]1[C@H]([C@@H](O[C@H](COC)[C@H]1OP(O[Na])(O[Na])=O)OC[C@@H]2[C@H]([C@@H]([C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(O[Na])(O[Na])=O)O2)OCCCCCCCCCC)O)NC(CCCCCCCCC/C=C\CCCCCC)=O

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• [1]. Younan P, et al. The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge. mBio. 2017 Apr 25;8(2):e00226-17  [Content Brief]

  [2]. Sun Y, et al. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1247-54.  [Content Brief]