2. Anti-infection
  3. Antibiotic Bacterial
  4. Fabimycin

Fabimycin is a FabI inhibitor with potent antibacterial activity against gram-negative bacteria. Fabimycin is effective against drug-resistant gram-negative Infections in vivo.

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Fabimycin

Fabimycin Chemical Structure

CAS No. : 2651965-71-6

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Fabimycin Related Antibodies

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Description

Fabimycin is a FabI inhibitor with potent antibacterial activity against gram-negative bacteria. Fabimycin is effective against drug-resistant gram-negative Infections in vivo[1].

In Vitro

Fabimycin shows outstanding activity against S. aureus (MIC: 4 ng/mL), E. coli MG1655 (MIC: 2 μg/mL)[1].
Fabimycin (4 μg/mL) inhibits 90% of the strainsagainst a panel of 100 K. pneumoniae clinical isolates[1].
Fabimycin enhances the stability of the enzyme-inhibitor complex significantly more than the less active enantiomer in both E. coli and A. baumannii versions of FabI[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fabimycin Related Antibodies
In Vivo

Fabimycin (Intramuscular injection, 5 mg/kg, 2 and 7 h postinfection) shows significant great reduction of bacterial burden in Neutropenic mouse thigh infection initiated in CD-1 mice with S. aureus[1].
Fabimycin (intraperitoneal injection) is tolerated in mice with an MTD of >200 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute pneumonia murine or neutropenic mouse thigh infection model, initiated in CD-1 mice with A. baumannii[1]
Dosage: 50 mg/kg
Administration: Intramuscular injection, 4, 23, and 41 h postinfection (pneumonia model), or 2, 6, and 11 h postinfection (thigh infection)
Result: Achieved a >3‑fold decrease in log(CFU/lung) and >2-fold decrease log(CFU/thigh) relative to the vehicle.
Animal Model: Urinary tract infections (UTIs) model (C3H/HeJ mice)[1]
Dosage: 33.3 mg/kg
Administration: Intravenous injection, three times a day,
Result: Achieved 3.0, 2.8, 2.9, and 1.9 log10 reductions in bacterial load relative to the vehicle in the spleen, bladder, liver, and kidney tissues, respectively.
Animal Model: Neutropenic female BALB/c mice infected with drug-resistant A. baumannii (pharmacokinetic assay)[1]
Dosage: 20, 50, 75, 100 mg/kg
Administration: Intravenous injection, for a single dose
Result: Pharmacokinetic profile of Fabimycin.
pharmacokinetic property AUClast (h•μg/mL) T1/2 (h) CL (mL/min/kg) Cmax (μg/mL)
100 mg/kg 69.8 1.4 23.5 47.3
75 mg/kg 45.4 1.4 26.9 34.6
Masse moléculaire

440.92

Formule

C23H25ClN4O3
CAS No.
SMILES

O=C(/C=C/C(C=C1CC[C@@H]2[NH3+])=CN=C1NC2=O)N(C)CC(O3)=C(C)C4=C3C=CC=C4.[Cl-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Fabimycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fabimycin2651965-71-6AntibioticBacterialInhibitorinhibitorinhibit

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