Fozivudine tidoxil
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription. Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- CAS No.: 141790-23-0
- Formula: C35H64N5O8PS
- Molecular Weight:745.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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HIV |
Fozivudine tidoxil (BM-211290) is a member of the nucleoside analogue reverse transcriptase inhibitor (NRTI) family[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Specific pathogen-free cats at 6 months of age[1]
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Dosage:45 mg/kg
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Administration:PO; twice daily; one day before FIV challenge for a total of six weeks
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Result:Effective at lowering plasma- and cell-associated viremia at two weeks post-feline immunodeficiency virus (FIV) infection with a trend toward lower plasma- and cell- associated viremia at four and six weeks post-infection (PI).
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 141790-23-0
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Molecular Weight 745.95
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Formula C35H64N5O8PS
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SMILES
O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2N=[N+]=[N-])([H])O[C@@H]2CO[P](OCC(OCCCCCCCCCC)CSCCCCCCCCCCCC)(O)=O
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Synonyms
BM-211290
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Michelle M Miller, et al. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic During Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012 Jun;4(6):954-62. [Content Brief]
[2]. P M Girard, et al. Phase II Placebo-Controlled Trial of Fozivudine Tidoxil for HIV Infection: Pharmacokinetics, Tolerability, and Efficacy. J Acquir Immune Defic Syndr. 2000 Mar 1;23(3):227-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fozivudine tidoxil Related Classifications
HY-126781 Related Classifications
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