1. Anti-infection
    Cell Cycle/DNA Damage
  2. HIV
    DNA/RNA Synthesis
  3. Fozivudine tidoxil

Fozivudine tidoxil (Synonyms: BM-211290)

Cat. No.: HY-126781
Handling Instructions

Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of drug, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription.

For research use only. We do not sell to patients.

Fozivudine tidoxil Chemical Structure

Fozivudine tidoxil Chemical Structure

CAS No. : 141790-23-0

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Description

Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of drug, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription[1][2].

IC50 & Target[1]

HIV

 

In Vitro

Fozivudine tidoxil (BM-211290) is a member of the nucleoside analogue reverse transcriptase inhibitor (NRTI) family[1].

In Vivo

Fozivudine tidoxil (BM-211290; 45 mg/kg; PO; twice daily; one day before FIV challenge for a total of six weeks) is effective at lowering plasma- and cell-associated viremia at two weeks post-FIV infection[1].

Animal Model: Specific pathogen-free cats at 6 months of age[1]
Dosage: 45 mg/kg
Administration: PO; twice daily; one day before FIV challenge for a total of six weeks
Result: Effective at lowering plasma- and cell-associated viremia at two weeks post-feline immunodeficiency virus (FIV) infection with a trend toward lower plasma- and cell- associated viremia at four and six weeks post-infection (PI).
Molecular Weight

745.95

Formula

C₃₅H₆₄N₅O₈PS

CAS No.

141790-23-0

SMILES

O=C(NC1=O)N(C=C1C)[[email protected]](C[[email protected]@H]2N=[N+]=[N-])([H])O[[email protected]@H]2CO[P](OCC(OCCCCCCCCCC)CSCCCCCCCCCCCC)(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Fozivudine tidoxilBM-211290BM211290BM 211290HIVDNA/RNA SynthesisHuman immunodeficiency virusorallythioetherlipid-zidovudineZDVconjugateNRTIDNAviralreplicationRTreverse-transcriptionInhibitorinhibitorinhibit

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Fozivudine tidoxil
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HY-126781
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