2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Fresolimumab

Fresolimumab  (Synonyms: GC1008)

Cat. No.: HY-P99020 Purity: 99.51%
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Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease.

For research use only. We do not sell to patients.

CAS No. : 948564-73-6

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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Fresolimumab

Cell Imaging/Staining
IF

    Fresolimumab purchased from MedChemExpress. Usage Cited in: Cells. 2023 Jun 14;12(12):1624.  [Abstract]

    Fresolimumab (Neutralizing antibody against TGF-βs) (10 μg/mL; 7 days). Illustration of cell morphology by phase-contrast images. The images were acquired using a phase-contrast microscope with X10 objective. Cropped images were used to illustrate cell morphology. Scale bar = 100 µm.

    Fresolimumab purchased from MedChemExpress. Usage Cited in: Cells. 2023 Jun 14;12(12):1624.  [Abstract]

    Fresolimumab (Neutralizing antibody against TGF-βs) (10 μg/mL; 4 weeks). Illustrative images. Cell lateral membranes were stained in green by NCAM and the nuclei were counter-stained in blue using DAPI. A higher magnification (X40) was added in order to show the cell morphology. The images were taken in the center of each well. Images of the same magnification were acquired with the same parameters. The scale bar was 200 µm for X10 images and 50 µm for X40 images.

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    • Customer Review

    Description

    Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease[1][2][3][4].

    Isotype

    Human IgG4 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    TGFB1
    In Vivo

    Fresolimumab (10-3000 μg/kg; i.v.; single administration) requires a high dose (3 mg/kg) to obtain a statistically significant inhibitory effect in Bleomycin (HY-108345)-induced acute lung injury rats, inhibiting inflammatory cell infiltration, lung tissue damage[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Gene ID

    7040  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    144.4 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Fresolimumab]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG4 kappa
    Biological Activity
    • Immobilized TGF beta 1/TGFB1 Protein, Human can bind Fresolimumab. The EC50 for this effect is 67.28 ng/mL.
    • Flow Cytometry analysis of PC-3 cells labelling TGFB1 (red) with Fresolimumab (anti-TGFB1) (HY-P99020). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG4 kappa (HY-P99003). Black-Unlabelled control, cells without incubation with primary antibody.
    Purity & Documentation

    Purity: 99.51%

    SDS (251 KB)

    COA (231 KB) SDS-PAGE (83 KB) SEC-HPLC (192 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Fresolimumab Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fresolimumab948564-73-6GC1008GC 1008GC-1008TGF-beta/SmadTransforming growth factor betaTGF-β monoclonal antibodyTGF-β1TGF-β2TGF-β3cancerfibrotic diseasesInhibitorinhibitorinhibit

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