GA-017

Name: GA-017
Brand: MedChemExpress
SKU: HY-147082
Rating: 5.0 (7 reviews)

Cat. No.: HY-147082 Purity: 98.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 2351906-74-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 7 publication(s) in Google Scholar

7 Publications Citing Use of MCE GA-017

•SSRN. 2025 Jan 3.

RT-PCR

Cell Migration/Invasion Assay

: GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]; ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) and K-975 for 24 h. Then, qRT-PCR was used to detect the expression of TEAD1 and TEAD4.

: GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]; GA-017 (10 μM) for 24 h. Wound healing assay (scale bar =100 μm) was performed to detect the changes of NCI-H520 cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

: GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]; GA-017 (10 μM) for 24 h. Transwell assay (scale bar =50 μm) was performed to detect the changes of cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

: GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]; ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) for 24 h or K-975. Then, qRT-PCR was performed to detect the expression of CSF1.

: GA-017 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Aug 18:S1097-2765(24)00633-6. [Abstract]; Caspase-1 (p20) and gasdermin D (cleaved N-term) processing upon NLRP3 inflammasome in BMDM cells with or without the treatment of TRULI and GA-017 (10 μM, 5h) .

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View All Isoforms

YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Lats1

Lats2

YAP/TAZ

In Vitro

GA-017 suppresses the cell death of HUVECs and promotes their cell growth^[1].
GA-017 facilitates SKOV3 cell growth, with an EC₅₀ of 3.51 ± 0.26 μM^[1].
GA-017 competitively inhibited LATS1 and 2 against ATP, with K_i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

343.38

화학식

C₁₈H₂₁N₃O₄

CAS No.

2351906-74-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9122 mL	14.5611 mL	29.1223 mL
5 mM	0.5824 mL	2.9122 mL	5.8245 mL
10 mM	0.2912 mL	1.4561 mL	2.9122 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.95%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB) HNMR (272 KB) LCMS (123 KB)

Handling Instructions (2659 KB)

References

[1]. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9122 mL	14.5611 mL	29.1223 mL	72.8056 mL
	5 mM	0.5824 mL	2.9122 mL	5.8245 mL	14.5611 mL
	10 mM	0.2912 mL	1.4561 mL	2.9122 mL	7.2806 mL
	15 mM	0.1941 mL	0.9707 mL	1.9415 mL	4.8537 mL
	20 mM	0.1456 mL	0.7281 mL	1.4561 mL	3.6403 mL
	25 mM	0.1165 mL	0.5824 mL	1.1649 mL	2.9122 mL
	30 mM	0.0971 mL	0.4854 mL	0.9707 mL	2.4269 mL
	40 mM	0.0728 mL	0.3640 mL	0.7281 mL	1.8201 mL
	50 mM	0.0582 mL	0.2912 mL	0.5824 mL	1.4561 mL
	60 mM	0.0485 mL	0.2427 mL	0.4854 mL	1.2134 mL

GA-017 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GA-0172351906-74-4GA017GA 017Large Tumor Suppressor (LATS)YAPLarge Tumor SuppressorYes-associated proteinSKOV3 cellsHUVECsserine/threonine protein kinaseshigh-throughput screeninginhibitorLATSHippo pathwayInhibitorinhibit

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GA-017

고객리뷰

GA-017 Related Antibodies

7 Publications Citing Use of MCE GA-017

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

GA-017 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

GA-017 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report